The invention discloses a manufacturing method of joint prostheses and a manufacturing method of trial molds of the joint prostheses. The manufacturing method of the joint prostheses is characterizedby comprising the following steps: (1) three-dimensional models of
thigh bones and tibias are established based on medical image data of joints of a patient; (2) the three-dimensional models, obtainedin the step (1), of the
thigh bones and the tibias are subjected to
simulation osteotomy through
software; (3) according to the
osteotomy amount in the step (2) and the three-dimensional models, obtained in the step (1), of the
thigh bones and the tibias, three-dimensional models of the thigh
bone prosthesis, the
tibia prosthesis and the
meniscus prosthesis are designed; (4) according to the three-dimensional models, designed in the step (3), of the thigh
bone prosthesis, the
tibia prosthesis and the
meniscus prosthesis, the thigh bone trial mold, the
tibia trial mold and the
meniscus trial mold are designed; and (5) according to the three-dimensional models of the prostheses designed in the step (3) and the trial molds designed in the step (4), corresponding parts are processed. The replaced joint prostheses and the trial molds corresponding to the joint prostheses are designed, thus the trial molds and the joint prostheses are optimally matched, and the joint prostheses and the patient are optimally matched.