2 results about "Fibroblast" patented technology

The invention relates to the technical field of skin care products, and particularly relates to anti-freeze hand cream and a preparation method of same. The anti-freeze hand cream is prepared from the raw materials including, by weight, 10-20 parts of extract of prunus mume, 10-15 parts of allantoin, 0.01-0.5 parts of a stem cell secretion factor, 30-40 parts of an emulsifier, 10-20 parts of squalane and 15-25 parts of water. The anti-freeze hand cream can effectively protect hands and comprehensively care hands, can improve the capability of synthesizing collagen proteins by fibroblasts in skin and can repair cells, improve cell metabolism and activate senile cells. The anti-freeze hand cream also has a delicate fragrance and can refresh mood of people, and is comfortable to use.

Identification and use of compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin including (a) bringing at least one test compound in contact with a sample of fibroblasts, (b) measuring the expression or the activity of at least one microRNA chosen from miR-134 and miR-152 in said fibroblasts, and (c) selecting the compounds for which an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the expression or an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the activity of at least one microRNA is measured in the fibroblasts treated in (a) compared with the untreated fibroblasts.