Provided are vesicles derived from
bacteria belonging to the
genus Cupriavidus, a composition and a use thereof, wherein the vesicles or composition may be usefully used for the purpose of developing a method of diagnosing a malignant diseases such as gastric
cancer, colon
cancer,
pancreatic cancer, cholangiocarcinoma,
breast cancer,
ovarian cancer,
bladder cancer,
prostate cancer,
head and neck cancer,
lymphoma, and the like, heart diseases such as
cardiomyopathy,
atrial fibrillation, variant
angina, and the like, chronic obstructive
pulmonary disease,
stroke, diabetes,
kidney failure,
dementia, Parkinson's
disease, or depression.