The invention relates to an azithromycin dispersible tablet and a preparation method thereof. The azithromycin dispersible tablet is prepared by the following steps: by adopting a fluid bed bottom spraying technology, coating azithromycin by using a suspension of calcium carbonate and a water-insoluble macromolecular polymer to prepare an azithromycin microcapsule; and then uniformly mixing the azithromycin microcapsule with other pharmaceutically acceptable auxiliary materials of the azithromycin and tabletting, wherein the water-insoluble macromolecular polymer is selected from one or more of acrylic resin, ethyecellulose and hydroxypropyl methylcellulose phthalate. Compared with the prior art, the azithromycin dispersible tablet disclosed by the invention has the advantages of good taste, fast dissolution and simple preparation process.