2 results about "Isothiocyanate" patented technology

The invention discloses a (S)-1-(3-hydroxy-1-phenylpropyl)thiourea unilateral-modified Fe-Anderson-type heteropoly acid catalyst, a preparation method and an application thereof. According to the invention, ammonium molybdate and ferric sulfate are reacted under acidic condition to generate Fe-Anderson-type heteropoly acid parent; then heteropoly acid parent and tris(hydroxymethyl)aminomethane are reacted under backflow condition to obtain amino unilateral-modified Fe-Anderson-type polyoxometallate; (S)-1-(3-hydroxy-1-phenylpropyl)isorhodanate is synthesized; and finally, polyoxometallate and (S)-1-(3-hydroxy-1-phenylpropyl)isorhodanate are subjected to the reaction to obtain the target product. The preparation method has the advantages of simple process, high yield, mild reaction condition, and environment friendlessness; the catalyst can be used for a self-oxidation coupling reaction of a aryl methylamine compound, and has the advantages of environment pollution and high efficiency, high corresponding selectivity, and easy recovery and utilization.

The invention relates to a thiazole derivative containing aminoglucose and coumarin, and also relates to a synthetic method of the derivative. The method includes: firstly reacting 2-deoxy-2-isothiocyanate-1,3,4,6-tetra-O-benzyl-beta-D-glucopyranose with ammonia gas to synthesize an intermediate that is glycosyl thiourea; and then reacting the glycosyl thiourea with a substituted 3-(bromoacetyl) coumarin derivative to synthesize N-(1,3,4,6-tetra-O-benzyl-beta-D-glucopyranose-2-yl)-4-(substituted coumarin-3-yl)-1,3-thiazole-2-amine. The method is simple and safe to operate, low in environment pollution, high in yield, and simple in after-treatment. The synthesized thiazole derivative has high suppression function on acetylcholin esterase, and has a wide application prospect in the field ofpreparing anti-(acetylcholin esterase) medicines.