3 results about "Pyrrolidine" patented technology

A composition for use as a stain blocker and a method of treating substrates therewith, said composition comprising a polymer of Formula 1 having the following repeating units in random sequence

wherein

• • R¹ is H, methyl or ethyl;
  • R² and R³ are each independently H, C₁ to about C₁₀ alkyl, —COOR⁴, CONR⁵R⁶, or —CN;
  • R⁴ is M, C₁ to about C₂₀ alkyl, or C₆ to C₁₀ aryl;
  • R⁵ and R⁶ are each independently H, C₁ to C₁₀ alkyl, C₆ to C₁₀ aryl, or R⁵ and R⁶ together with the nitrogen atom form a morpholine, pyrrolidine, or piperidine ring;
  • R⁷ is a C₄ to C₈ alkyl group; M is H, an alkali metal or alkali earth metal; h is about 10 to 100 mole %; i is 0 to about 80 mole %; j is 0 to about 60 mole %; k and n are each independently 0 to about 40 mole %; and m is 0.01 to about 0.5; provided that h+i+j+k+n equals 100, and provided that i+j+k+n is greater than zero, except when h is 100%.

The invention discloses a synthesis method of vildagliptin, and relates to the technical field of synthesis of pyrrolidine heterocyclic compounds. The synthesis method comprises the following steps: (1) obtaining (S)-1-(2-oxoacetyl) pyrrolidine-2-formonitrile through acid amine condensation reaction by using (S)-pyrrolidine-2-formonitrile and glyoxylic acid as the raw materials; (2) obtaining 2-((S)-2-cyanopyrrolidine-1-yl)-1-hydroxyl-2-oxo ethyl sulfonic acid sodium through addition reaction of (S)-1-(2-oxoacetyl) pyrrolidine-2-formonitrile and sodium metabisulfite; (3) obtaining vildagliptin through reductive amination reaction of 2-((S)-2-cyanopyrrolidine-1-yl)-1-hydroxyl-2-oxo ethyl sulfonic acid sodium and 3-amino-1-adamantanol. The synthesis method of vildagliptin is fewer in reaction steps, high in yield, easy in removal of byproducts, simple and convenient to operate, lower in cost and capable of obtaining a product with high chemical purity and optical purity.