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Application and preparation method of candidate strain of human type-3 adenovirus expressed human type-14 adenovirus neutralization epitope vaccine,Recombinant baculovirus for expressing spike protein of chicken infectious bronchitis virus and application thereof

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A recombinant virus is a virus produced by recombining pieces of DNA using recombinant DNA technology. This may be used to produce viral vaccines or gene therapy vectors. It is also used to refer to naturally occurring recombination between virus genomes in a cell infected by more than one virus strain. This occurs either by homologous crossing over of the nucleic acid strands or by reassortment of genomic segments. Both these and mutation within the virus have been suggested as ways in which influenza and other viruses evolve. An example of a recombinant virus is Western equine encephalitis virus (WEE), which is a recombinant virus between two other closely related yet distinct encephalitis viruses. In addition, reassortment is most important for pandemic influenza viruses.

Application and preparation method of candidate strain of human type-3 adenovirus expressed human type-14 adenovirus neutralization epitope vaccine

InactiveCN105238766AAvoid infectionRetain major antigenic activityMicroorganism based processesAntiviralsAntigenHuman type

The invention relates to the technical field of genetic engineering of recombinant viruses, in particular to an application and preparation method of a candidate strain of a human type-3 adenovirus expressed human type-14 adenovirus neutralization epitope vaccine. Two human type-14 adenovirus neutralization epitopes are respectively embedded to hexons of human type-3 adenoviruses to be displayed on the surfaces of the hexons. The candidate strain of the vaccine is capable of inducing strong anti-HAdv14 and anti-HAdv3 infection immunoreactions and can be used for preparation of bivalent vaccines for prevention of HAdv14 and HAdv3 infection.

Application and preparation method of candidate strain of human type-3 adenovirus expressed human type-14 adenovirus neutralization epitope vaccine

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Owner:东莞市第八人民医院

Recombinant baculovirus for expressing spike protein of chicken infectious bronchitis virus and application thereof

ActiveCN101948814AAvoiding the dangers of loose poisonsSuitable for useViruses/bacteriophagesFermentationAntigenShuttle vector

The invention relate to a recombinant baculovirus for expressing spike protein of chicken infectious bronchitis virus and application thereof, belonging to the biotechnical field. The recombinant baculovirus is prepared by a method comprising the following steps: obtaining S genes; building and indentifying a recombinant transfer vector pFastBacI-S; building and indentifying a recombinant shuttle vector AcIBV-SBacmid which infects Sf9 inset cells; and obtaining the recombinant baculovirus vAcIBV-S for expressing the spike protein of the chicken infectious bronchitis virus. The invention further provides the application of the recombinant baculovirus in the aspect of detecting chicken infectious bronchitis virus antibodies. The recombinant baculovirus can be used for detecting the chicken infectious bronchitis virus antibodies, thereby avoiding the risk of easy toxin diffusion when live virus serves as an antigen. The recombinant baculovirus can be used for detecting the chicken infectious bronchitis virus antibodies, can be used for quarantine on a large scale, and is especially suitable for use of quarantine departments at the basic level.

Owner:NAT VETERINARY BIOLOGICAL PROD ENG TECH RES CENT +1

2 results about "Recombinant virus" patented technology

Application and preparation method of candidate strain of human type-3 adenovirus expressed human type-14 adenovirus neutralization epitope vaccine

Recombinant baculovirus for expressing spike protein of chicken infectious bronchitis virus and application thereof

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