2 results about "Sodium methoxide" patented technology

The invention belongs to the field of medicinal chemical synthesis and in particular relates to a method for preparing 4-amino-2,6-dihydroxypyrimidine by virtue of a dry frying process. The method forpreparing 4-amino-2,6-dihydroxypyrimidine by virtue of the dry frying process comprises the following concrete steps: by taking sodium methoxide dry powder, urea and methyl cyanoacetate as raw materials, reacting under certain conditions, heating at a certain temperature, steaming out generated methanol, and finally generating 4-amino-2,6-dihydroxypyrimidine. According to the invention, yield of4-aminopyrimidine obtained through cyclization reaction can reach 80-85%, and product purity is more than 99%. Compared with a liquid-phase cyclization method, the method provided by the invention hasthe advantages that reaction yield can be improved by more than 15%, reaction period is reduced to be 2-3 hours from the original more than 8 hours, and no water methanol is produced, so that pollution of organic wastewater is greatly reduced, preparation cost and energy consumption of 4-amino-2,6-dihydroxypyrimidine are greatly reduced, and the method provided by the invention is hopeful to being applied to industrial production.

The invention provides an analysis method of a fluorine-containing surfactant. The method comprises the following steps: 1, extracting: adding a sample containing the fluorine-containing surfactant to a first solvent and concentrated hydrochloric acid, stirring the sample, the first solvent and the concentrated hydrochloric acid, separating soluble components and insoluble components, collecting the soluble components, and carrying out reduced pressure concentration on the collected soluble components until the soluble components are dry; 2, carrying out a halogenation reaction: adding a halogenation agent to the soluble components obtained in step 1, and carrying out the halogenation reaction; 3, carrying out electrophilic substitution: carrying out reduced pressure concentration on a reaction product obtained in step 2, adding a second solvent and sodium methoxide, heating the reaction product, the second solvent and sodium methoxide, adding resorcinol, carrying out an electrophilic substitution reaction, and carrying out reduced pressure concentration after the reaction is completed in order to obtain a reaction product A; and 4, carrying out LC-MS detection on the reaction product A in step 3, wherein the first solvent is one or more of chlorohydrocarbon, acetonitrile and toluene, and the second solvent is one or more of acetonitrile and toluene.