Coating solution of medicament for reducing stimulation of medicament to stomach

A coating solution and drug technology, applied in drug delivery, pharmaceutical formulations, plant raw materials, etc., can solve the problems of gastric mucosal irritation, impact on application, and easy dissolution, so as to avoid degradation, prevent gastric mucosal irritation, and ensure drug The effect of curative effect

Active Publication Date: 2009-08-05
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] With the improvement of people's awareness of advocating nature, people pay more and more attention to traditional Chinese medicine. Due to the characteristics of traditional Chinese medicine, some traditional Chinese medicines such as timosaponin, garlic oil, angelica oil, tripterygium wilfordii extract, and whole-leaf green orchid volatile oil are used clinically. Gastric mucosal irritation exists duri

Method used

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  • Coating solution of medicament for reducing stimulation of medicament to stomach
  • Coating solution of medicament for reducing stimulation of medicament to stomach

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0020] Example 1: Preparation of Garlic Oil Soft Capsule Coating

[0021] Prescription: garlic oil 50g soybean oil 160g

[0022] Rubber prescription: gelatin 10kg glycerin 4kg purified water 10kg ethyl parahydroxybenzoate 50g

[0023] Coating formulation: o-methacrylic acid-methacrylate copolymer (Eudragit S) 30g, polypropylene No. 3 resin 20g, castor oil 20ml, dimethicone 10ml, talc 28g, propylene glycol 20ml, add ethanol to make 1000ml.

[0024] Method:

[0025] (1) Preparation of coating solution: take by weighing o-methacrylic acid-methacrylate copolymer (Eudragit S), polypropylene No. Acrylic acid-methacrylate copolymer (Eudragit S), polypropylene No. III was soaked in ethanol for 18 hours, propylene glycol, castor oil and dimethicone were added, and ethanol was added to a sufficient amount. Serve.

[0026] (2) Preparation of drug core:

[0027] Glue A: Weigh glycerin, purified water and ethyl p-hydroxybenzoate according to the recipe, put them in a glue tank, stir and

Example Embodiment

[0030] Example 2: Preparation of Futongning Soft Capsule Coating

[0031] Prescription: Angelica volatile oil 10g, soybean oil 90g

[0032] Rubber prescription: gelatin 10kg glycerin 4kg purified water 10kg ethyl parahydroxybenzoate 50g

[0033] Coating formulation: 20 g of o-methacrylic acid-methacrylate copolymer (Eudragit S), 30 g of polypropylene No. 3 resin, 30 ml of castor oil, 5 ml of dimethicone, 30 g of talc, 30 ml of propylene glycol, and ethanol to make 1000 ml.

[0034] Method:

[0035] (1) Preparation of coating solution: take by weighing o-methacrylic acid-methacrylate copolymer (Eudragit S), polypropylene No. Acrylic acid-methacrylate copolymer (Eudragit S), polypropylene No. III was soaked in ethanol for 12 hours, propylene glycol, castor oil and dimethicone were added, and ethanol was added to a sufficient amount. Serve.

[0036] (2) Preparation of drug core:

[0037] Glue A: Weigh glycerin, purified water and ethyl p-hydroxybenzoate according to the recipe,

Example Embodiment

[0040] Example 3: Preparation of Tripterygium wilfordii tablet coating

[0041] Prescription: Tripterygium wilfordii extract 33g starch 267g

[0042] Coating formulation: 50 g of o-methacrylic acid-methacrylate copolymer (Eudragit S), 10 g of polypropylene III resin, 10 ml of castor oil, 15 ml of dimethicone, 15 g of talc, 10 ml of propylene glycol, and ethanol to make 1000 ml.

[0043] Method:

[0044] (1) Preparation of coating solution: take by weighing o-methacrylic acid-methacrylate copolymer (Eudragit S), polypropylene No. Acrylic acid-methacrylate copolymer (Eudragit S), polypropylene No. III was soaked in ethanol for 24 hours, propylene glycol, castor oil and simethicone were added, and then ethanol was added to a sufficient amount, stirred well, and talc powder was added when using, Serve.

[0045] (2) Preparation of drug core: Weigh Tripterygium wilfordii extract and starch according to the prescription, stir to mix, and press into tablets.

[0046](3) Enteric coati

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Abstract

The invention relates to an enteric coating solution for a medicine, which is characterized in that the coating solution takes ethanol as a solvent, and each 1,000 volume portions of the coating solution contains the following raw materials: 20 to 50 weight portions of o-methacrylic acid-metacrylic acid ester copolymer (Eudragit S), 10 to 30 weight portions of polypropylene NO. 3 resin, 10 to 30 volume portions of castor oil, 5 to 15 volume portions of dimeticone, 15 to 30 weight portions of talcum powder, and 10 to 30 volume portions of propylene glycol. The method can form a layer of membrane outside a preparation; and the enteric coating solution does not disintegrate in acid environments of gastric acid, and disintegrates to release the medicine in alkaline environments of small intestines so as to prevent the medicine which has irritation effect on gastric mucosa from irritating the gastric mucosa, also prevent the medicine from being degraded by the gastric acid, and ensure the therapeutic effect of the medicine.

Description

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Claims

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Application Information

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Owner SICHUAN KELUN PHARMA CO LTD
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