Preparation method of nanometer strontium-doped hydroxyapatite powder

A strontium hydroxyapatite and powder technology, which is applied in the fields of chemical and biological materials, can solve the problems of not easy degradation, poor osteoinductivity, high brittleness, etc., and achieves the effect of simple experimental method and loose experimental conditions.

Inactive Publication Date: 2013-05-08
CHONGQING UNIV
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AI Technical Summary

Benefits of technology

This new technology allows scientists to study materials that have been modified by adding certain substances into them without affecting their original properties or making it difficult to work on again afterward. It's easy to operate at different temperatures and concentrations while also being cost-effective due to its simplicity compared to previous methods.

Problems solved by technology

This patents discuss various technical problem addressed in this patented text relates to finding ways for making stronger or less expensive prosthydritis replacements without compromizing their original function like blood clots due to lack of autogenous stem cells present inside them. To solve this issue, we propose introducing strontia instead of hormonal ones, but current methods result in impurities from unnatural sources and may harm health issues over long periods of use. Therefore, there is an urgent demand for new techniques to create nanocages called strontiolites, specifically stronickels, within hydrazone gel structures made up mostly of amorphic calcium carbonate(HCA), while maintaining structural integrity and being able to effectively promote growth and bondage between proteins.

Method used

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  • Preparation method of nanometer strontium-doped hydroxyapatite powder
  • Preparation method of nanometer strontium-doped hydroxyapatite powder

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preparation example Construction

[0020] The preparation method of nanometer strontium-doped hydroxyapatite powder of the present invention, its preparation step is, see also figure 1 :

[0021] (1) According to the Sr / (Ca+Sr) molar ratio of (3~12):100 and (Ca+Sr) / P molar ratio of 10:6 to Ca(NO 3 ) 2 4H 2 O, Sr(NO 3 ) 2 4H 2 O and Na 2 HPO 4 12H 2 O for ingredients.

[0022] (2) Ca(NO 3 ) 2 4H 2 O and Sr(NO 3 ) 2 4H 2 O dissolves in water together to form 1# solution, and Ca in 1# solution 2+ with Sr 2+ The concentration sum is 0.1~0.25mol / L; the Na 2 HPO 4 12H 2 O was dissolved in water to form 2# solution, and the pH values ​​of 1# solution and 2# solution were adjusted to 9~11 with NaOH solution.

[0023] (3) Under stirring conditions, slowly add 2# solution to 1# solution to form a mixed solution, and use NaOH solution to adjust the pH value of the mixed solution to 9~11; when mixing, carry out under stirring conditions to make it fully Mix well.

[0024] (4) After the t

Embodiment 1

[0032] The transmission electron micrograph of the strontium-doped HA prepared in embodiment 1 is shown in figure 2 , The particle size of the powder is about 70nm. In Example 1, the molar ratio of Sr / (Ca+Sr) is 5:100, and the obtained nano-doped HA powder is recorded as Sr5HA.

Embodiment 2

[0034] Weigh 0.0025mol (about 0.931g) Na 2 EDTA·2H 2 O powder, 0.01125mol (about 2.657g) Ca(NO 3 ) 2 4H 2 O and 0.00125mol (about 0.355g) Sr(NO 3 ) 2 ·6H 2 O powder, dissolved in 40ml of deionized water in turn and fully stirred to dissolve, and constant volume with a 50ml volumetric flask to prepare 1# solution; weigh 0.0075mol (about 2.686g) of Na 2 HPO 4 12H 2 O was dissolved in 40 ml of deionized water and stirred until completely dissolved to prepare 2# solution; adjust the pH of 1# and 2# solutions to 10 with the 5mol / L NaOH solution prepared in advance, and under the condition of vigorous stirring, Add the 2# solution to the 1# solution drop by drop. After the dropwise addition, 100ml of the mixed solution is obtained. Use 5mol / L NaOH solution to adjust the pH of the mixed solution to 10; , after the stirring is completed, adjust the pH=10 with 5mol / L NaOH again, and then put the mixed solution into a polytetrafluoroethylene reactor to make it undergo hydrot

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Abstract

The invention discloses a preparation method of nanometer strontium-doped hydroxyapatite powder. The preparation method comprises the following steps of: dissolving prepared Ca(NO3)2.4H2O and Sr(NO3)2.4H2O in water to form a 1# solution, dissolving Na2HPO4.12H2O in water to form a 2# solution and adjusting the pH values of the 1# solution and the 2# solution to 9-11; slowly adding the 2# solutionto the 1# solution and adjusting the pH value of the mixed liquid to 9-11; heating the mixed liquid to 60-80 DEG C, stirring for 1-3h, and adjusting the pH value to 9-11; then heating to 130-170 DEG C, preserving the temperature for 4-8h and carrying out a hydrothermal reaction; carrying out cooling, extraction filtering, washing and drying in sequence after the hydrothermal reaction is ended to obtain the nanometer strontium-doped hydroxyapatite powder. The preparation method disclosed by the invention is simple, economic and controllable; experiment conditions are looser; purer strontium-doped HA (hydroxyapatite) powder with very even grain diameter can be obtained in the larger Ca/Sr rate and temperature range; and the preparation method disclosed by the invention is applied to industrial large-scale production.

Description

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Claims

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Application Information

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Owner CHONGQING UNIV
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