Combined medicine for preventing and treating tumors

[0027] Example 1: Study on anti-S180 tumor effect of cucurbitacin B (CuB) and coenzyme Q10 (Q10)

[0028] Experimental program:

[0029] Take Kunming mice, weighing 18-22 grams, male, inoculate S180 tumor in the armpit of the right forelimb, and wait until the tumor mass grows to be larger than 50 mm 2 At the time, they were randomly divided into 3 groups, each with 10 animals, and each group was given intragastric administration separately. The scheme is as follows:

[0030] Dosage: CuB: B( 5 mg / kg)

[0031] Q10: Q (50 mg / kg)

[0032] Mode of administration: CuB emulsion, B+Q composite emulsion

[0033] Control group: normal saline group

[0034] Experimental group: CuB group, CuB+Q10 group

[0035] The administration was continued for 14 days. Within 24 hours after the last administration, the animals were sacrificed and the tumors were weighed to calculate the tumor inhibition rate.

[0036] Results: The tumor inhibition rates of CuB group and CuB+Q10 group were 48.

[0038] Example 2: Study on anti-S180 tumor effect of cucurbitacin B (CuB) and taurine (T)

[0039] Experimental program:

[0040] Take Kunming mice, weighing 18-22 grams, male, inoculate S180 tumor under the armpit of the right forelimb, and wait until the tumor mass grows to more than 50 mm 2 At the time, they were randomly divided into 3 groups, 10 animals in each group, and each group was given intragastric administration separately. The scheme is as follows:

[0041] Dosage: CuB: 5 mg / kg

[0042] T: 300 mg / kg

[0043] Administration method: CuB emulsion, CuB+T composite emulsion

[0044] Control group: normal saline group

[0045] Experimental group: CuB emulsion group, CuB+T composite emulsion group

[0046] The administration was continued for 14 days. Within 24 hours after the last administration, the animals were sacrificed and the tumors were weighed to calculate the tumor inhibition rate.

[0047] Results: The tumor inhibition rates of CuB emulsion g

[0049] Example 3: Study on anti-H22 tumor effect of cucurbitacin B (CuB) and coenzyme Q10 (Q10)

[0050] Experimental program:

[0051] Take Kunming mice, weighing 18-22 grams, male, inoculate H22 tumor in the armpit of the right forelimb, and wait until the tumor mass grows to be larger than 50 mm 2 At the time, they were randomly divided into 3 groups, 10 animals in each group, and each group was given intragastric administration separately. The scheme is as follows:

[0052] Dosage: CuB: B( 5 mg / kg)

[0053] Q10: Q (50 mg / kg)

[0054] Mode of administration: CuB emulsion, B+Q composite emulsion

[0055] Control group: normal saline group

[0056] Experimental group: CuB group, CuB+Q10 group

[0057] The administration was continued for 14 days. Within 24 hours after the last administration, the animals were sacrificed and the tumors were weighed to calculate the tumor inhibition rate.

[0058] Results: The tumor inhibition rates of CuB group and CuB+Q10 group w