Topical and/or transdermal bioactive compound delivery system

Inactive Publication Date: 2006-03-30
NAT UNIV OF SINGAPORE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0018] According to another aspect, the present invention provides a non-aqueous bioactive compound delivery composition which is mad

Problems solved by technology

However, it is relatively difficult for the patient to accurately control the drug amount administered to the site of application.
Moreover, the compliance is usually poor because of the sticky feeling and soiling of clothes due to these dosage forms.
However, the existing technologies exhibit some disadvantages associated with the use of pressure sensitive adhesives (PSAs) in the fabrication of these dosage forms to allow the dosage forms to adhere on skin for a long period of time.
This type of system can load a relatively large amount of drug but dose dumping due to leakage from the reservoir is another disadvantage and the use of controlled release membrane also complicates the fabrication process.
Low drug capacity is a limitation besides the problems due to PSAs.
However, it is well known that these PSAs are essentially hydrophobic and are not suitable, in some cases, to be loaded with a hydrophilic polar drug, for long-term wear and wound care.
They usually lose their adhesive properties in the presence of moisture and thus, excessive perspiration of the skin is a detrimental factor to adhesive property of PSAs.
Dissolved addi

Method used

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  • Topical and/or transdermal bioactive compound delivery system
  • Topical and/or transdermal bioactive compound delivery system
  • Topical and/or transdermal bioactive compound delivery system

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0079] The composition of the matrix consisted of co-polymer of N-vinylacetamide and sodium acrylate (PNVA GE-167) of 9% (w / w) and the weight ratios of PNVA GE-167 to aluminium chloride and of propylene glycol to N-methyl-2-pyrrolidone were kept at 1.5:1 and 2:1, respectively.

examples 2-5

[0080] The compositions of the matrix consisted of PNVA GE-167 with different amount of 5% (Example 2), 7% (Example 3), 11% (Example 4) and 13% (Example 5), while the weight ratios of PNVA GE-167 to aluminium chloride at 1.5:1 and of propylene glycol to N-methyl-2-pyrrolidone at 2:1 were maintained constant.

examples 6-9

[0081] The compositions of the matrix consisted of 9% (w / w) of PNVA GE-167 and the weight ratio of propylene glycol to N-methyl-2-pyrrolidone was maintained at 2:1 but the weight ratios of PNVA GE-167 to aluminium chloride varied from 2.5:1 (Example 6), 2:1. (Example 7), 1:1 (Example 8) to 1:1.5 (Example 9).

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Abstract

Topical and/or transdermal bioactive compound delivery system The present invention provides a topical and/or transdermal bioactive compound delivery system comprising a non-aqueous matrix, the matrix comprising a water-sensitive bioactive compound. In particular, the matrix comprises a three-dimensional polymeric network comprising at least a co-polymer, at least a cross-linking agent, and at least a non-aqueous and/or non-volatile solvent and wherein the water-sensitive bioactive compound is housed by the three-dimensional network. Even more in particular, the matrix comprises a co-polymer of N-vinylacetamide and sodium acrylate aluminium chloride; N-methyl-2-pyrrolidone; propylene glycol; glycerine; and at least a water-sensitive bioactive compound.

Description

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Claims

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Application Information

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Owner NAT UNIV OF SINGAPORE
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