Bi-modal hyaluronate

a hyaluronate and bimodal technology, applied in the field of bimodal hyaluronate, can solve the problems of difficult delivery, inability to achieve the combination of desired theological properties of various fractions, and inability to manipulate the various fractions to achieve desired theological properties, etc., to achieve the effect of prolonging the duration of dispersive ovds in the anterior chamber, and reducing the effect of ovds

Inactive Publication Date: 2007-03-15
AMO REGINAL HLDG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While the bi-modal formulations in the Francese patents provide significant benefits over the Balazs formulations, Francese et al. nevertheless failed to appreciate how to manipulate the various fractions to achieve combinations of desired Theological properties.
They can be more difficult to deliver due to the less pronounced shear thinning viscosity and due to the high concentrations that are required for space maintenance.
Furthermore, their solution-like properties give dispersive OVDs longer duration in the anterior chamber when surgeons use high flow and increased vacuum.
These properties may also make it difficult to remove dispersive OVDs at the end of surgery.
If a surgeon fails to remove the OVD sufficiently, it can lead to an increased risk of transient increases in intraocular pressure (IOP).
However, under high flow and vacuum settings, there is a risk that a surgeon may prematurely eliminate the cohesive OVD from the anterior chamber.
The problem is that neither dispersive nor cohesive formulations are optimal for all aspects of all surgeries.
Clearly this adds the risk of viscoelastic confusion to a surgery, as well as additional cost and administrative burdens.

Method used

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Experimental program
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Embodiment Construction

[0029] Viscoelastic (VE) formulations can be characterized by a number of different physical parameters. The parameters of greatest interest herein are those judged to be important for explaining / predicting the function of the OVD in different steps during eye surgery, including the following:

[0030] 1. Rheology

[0031] 2. Molecular mass

[0032] 3. Concentration

[0033] 4. Osmolality

[0034] 5. Dynamic contact angle

[0035] 6. Distribution of molecular masses

[0036] 1. Rheology

[0037] Rheology is the science of deformation and flow of matter. A number of important parameters for the VE solutions can be revealed by performing various tests using a cone-plate rheometer.

[0038] Shear Viscosity Test. In one such test a VE-solution is put on a plate, and a cone having a defined geometry (diameter and cone angle) is lowered down into the solution, but stilt providing a specified gap between the cone and the plate. Depending on what features will be investigated, a torque (shear stress) is then...

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Abstract

Formulations and methods for protecting cell layers and tissues exposed to trauma are disclosed. Different molecular mass fractions of the same polymer can be used to better control the physical and chemical properties of the formulation. In this manner the benefits of both fractions, and not just the benefits of the average of the fractions, can be seen in the formulation.

Description

PRIORITY [0001] This application claims priority to U.S. Provisional Patent Application No. 60 / 715,016, filed Sep. 7, 2005 and U.S. Provisional Patent Application No. 60 / 715,926, filed Sep. 8, 2005, both of which are incorporated herein in their entirety.FIELD OF THE INVENTION [0002] The present invention relates to compositions and methods useful during cosmetic and surgical procedures. More specifically, this invention relates to compositions and methods involving polymers having differing molecular mass for protecting cell layers and tissues exposed to trauma, for example the trauma that is experienced during surgery. BACKGROUND [0003] When the natural lens of the eye becomes hazy or clouded, surgery is often performed to remove the impaired lens. During such surgery, the lens can be broken into a number of different particles and then removed using phacoemulsification. Ophthalmic viscosurgical devices (OVDs) are used to protect intraocular tissues, including the corneal endothel...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/785A61K31/737A61K31/728A61K31/717
CPCA61K9/0048A61K31/717A61K47/36A61K31/737A61K31/785A61K31/728A61P27/02
Inventor BERGMAN, ROLFLUNDQVIST, MARIAMANNBERG, STIGLUNDGREN, BJORNSHIMIZU, ROBERT
Owner AMO REGINAL HLDG
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