The invention belongs to the technical field of feeds, and particularly relates to a formula of a portunus trituberculatus feed suitable for factory breeding. The portunus trituberculatus feed suitable for factory breeding is prepared from the following components in parts by weight: 80-120 parts of defatted fish meal, 50-90 parts of steamed fish meal, 20-30 parts of shrimp shell meal, 27-40 parts of bean pulp, 80-120 parts of corn flour, 0.1-1 part of ginseng, 6-12 parts of white atractylodes rhizome, 6-12 parts of polyporus umbellatus, 2-9 parts of astragalus root, 6-12 parts of angelica, 2-7 parts of pilose asiabell root, 1-2 parts of poria cocos, 2-5 parts of lentinula edodes, 3-7 parts of agaric, 2-10 parts of licorice, 2-3 parts of coptis, 1-2 parts of garlic, 2-4 parts of vitamin mixture and 1-3 parts of mineral mixture. The formula has the advantages that multiple active ingredients have different regulation manners for the immune system of the body and are used together to facilitate comprehensive regulation, so that the phagocytic activity of body cells and the activity of lysozyme can be comprehensively improved, the resistance to pathogenic bacteria is improved, and the non-specific immunity is integrally improved.