The present invention discloses glucose polymer-based solutions and methods for their preparation, which solutions can be used in medical treatments such as dialysis treatments. The glucose polymer-based solution preferably comprises a first solution containing icodextrin having a pH in the range of about 1.5 to about 5.0 and a buffer solution in the pH range of from about 7.0 to about 12.0, constructed and arranged to allow the glucose polymer-based solution to Mixed before infusing into patient. The glucose polymer-based solutions of the present invention can be prepared at physiological pH with minimal glucose degradation products.