The invention discloses a fuel oil additive mixture, which is composed of the following formula components by mass percentage: 20-50 parts of triethylamine, 30-50 parts of ethylene glycol, 30-50 parts of ethylenediamine, 15-50 parts of acetone, 20-40 parts of ethyl acetate, 30-40 parts of isooctyl nitrate, 20-40 parts of nano-iron oxide, 30-50 parts of glyceryl monooleate, 10-30 parts of palmitic acid, 5-10 parts of carbon tetrachloride, and 10-30 parts of propylene dichloride. The fuel oil additive mixture provided by the invention can clear carbon deposit, clean the fuel oil system, enhance the power performance, improve atomization, save fuel oil, prevent corrosion, prevent rust and lubricate, protect the engine, reduce noise, reduce wear, prolong the engine life, eliminate black smoke, and lower emission.