The invention discloses a compound preparation for treating skin diseases of animals, and a preparation method of the compound preparation for treating skin diseases of animals, relates to the technical field of veterinary medicines, and solves the problem that outdoor applying is inconvenient. The compound preparation comprises the following components in parts by weight: 2 parts of ozone oil, 1.5 parts of olive oil, 1.5 parts of peppermint oil, 2 parts of matrine, 2 parts of camphor, 1 part of borneol, 3 parts of mint, 2 parts of common cnidium fruits, 2 parts of lithargyrum, 2 parts of Chinese galls, 1 part of fructus evodiae, 2 parts of dried ginger and 2 parts of herba violae. The preparation method of the compound preparation comprises the following steps of taking the ozone oil, thecamphor, the olive oil, the peppermint oil, the matrine, the borneol and the dried ginger for standby application; and picking the mint, the common cnidium fruits, the lithargyrum, the Chinese galls,the fructus evodiae and the herba violae, respectively removing impurities, performing thorough cleaning, performing cutting into segments or slices, and performing drying by airing. According to thecompound preparation and the preparation method thereof disclosed by the invention, infected parts of animals are slightly cleaned with a hydrogen peroxide solution and wiped and dried or not scoured, the compound preparation is applied and sprayed onto the infected parts of the animals, and the compound preparation is simple to prepare and convenient to use.