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2 results about "Virulence" patented technology

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Virulence is a pathogen's or microbe's ability to infect or damage a host. In the context of gene for gene systems, often in plants, virulence refers to a pathogen's ability to infect a resistant host. In most other contexts, especially in animal systems, virulence refers to the degree of damage caused by a microbe to its host. The pathogenicity of an organism - its ability to cause disease - is determined by its virulence factors. The noun virulence derives from the adjective virulent. Virulent can describe either disease severity or a pathogen's infectivity. The word virulent derives from the Latin word virulentus, meaning "a poisoned wound" or "full of poison."

Methods and compositions for suppressing virulence of methicillin resistant Staphylococcus aureus

ActiveUS9526774B1Polypeptide with localisation/targeting motifAntibody mimetics/scaffoldsAntigenVirulence

The present invention is directed to methods of suppressing the virulence of one or more virulence antigenic factors of methicillin resistant Staphylococcus aureus (MRSA). Aspects of the invention include administering of an expression vector alone or in conjunction with a fusion protein. The expression vector has a transcription unit encoding a fusion protein composed of a virulence antigenic factor of MRSA attached through a linker to the aminoterminal end of the ecd CD40 ligand. The fusion protein is composed of a virulence antigenic factor of MRSA and CD40 ligand and has the ability to generate antibodies which prevents host cell infection by suppressing virulence functions of MRSA.

Owner:MICROVAX

ORF074 (Open Reading Frame 074) gene deleted strain of infectious spleen and kidney necrosis virus as well as preparation method and application thereof

ActiveCN108384763AHigh immunity rateImproving immunogenicityViral antigen ingredientsVirus peptidesRenal necrosisNecrovirus

The invention provides an ORF074 (Open Reading Frame 074) gene deleted strain of an infectious spleen and kidney necrosis virus as well as a preparation method and application thereof. The ORF074 genedeleted strain is an attenuated viral strain prepared after the ORF074 gene is deleted from an infectious spleen and kidney necrosis viral strain. The invention also provides a selection marker carrying ORF074 gene deleted strain of the infectious spleen and kidney necrosis virus as well as a preparation method and application thereof. The selection marker carrying ORF074 gene deleted strain is an attenuated viral strain prepared after the ORF074 gene is deleted from the infectious spleen and kidney necrosis virus and further a selection marker gene is inserted into a gene deleted position through homologous recombination. The ORF074 gene deleted strain of the infectious spleen and kidney necrosis virus, which is provided by the invention, is an ORF074 knocked-out recombinant gene engineering vaccine, is lower in virulence, and is used for greatly reducing the morbidity and lethality of an immunized fish; the obvious immunization effect can be achieved by adopting immersion immunization; the injection is not needed, and the application value is extremely high.

Owner:SUN YAT SEN UNIV

2 results about "Virulence" patented technology

Methods and compositions for suppressing virulence of methicillin resistant Staphylococcus aureus

ORF074 (Open Reading Frame 074) gene deleted strain of infectious spleen and kidney necrosis virus as well as preparation method and application thereof

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