Cleaning fluid used for automatic biochemical analyzer

A technology of automatic biochemical analysis and cleaning solution, applied in the field of cleaning solution, can solve the problems of incompatibility of instruments, low residual rate of protein substances, inaccurate test indicators, etc., and achieve low residual rate of lipid substances and low protein content Substance residue rate, effect of good intra-batch reproducibility

Active Publication Date: 2009-07-01
SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology improves upon existing methods used in analyzers like automated blood cell counters (BCCs). It introduces various combinations of special chemical agents together with specific buffers into this cleaner solution. These improvements improve its ability to effectively clear impurities from samples while also reducing costs compared to current methods. Additionally, these new compositions help reduce contaminating particles or bubbles when injecting liquor onto them. Overall, they provide better performance than previously available systems without causing harmful side effects.

Problems solved by technology

This patented describes various issues associated with current automated biomedial chemical analysis machines (BMAC). Current cleanings systems suffer from limitations like lack of sufficient cleanability due to factors like pump efficiency during operation. Additionally, existing cleaning methods involve complicated procedures involving multiple steps, leading to increased costs and potentially causing damage to equipment.

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0070] Using water as a solvent, prepare an automatic biochemical analyzer alkaline cleaning solution according to the following weight percentage concentration ratio:

[0071] Tris 0.4%

[0072] H-95 2.5%

[0073] AEO-9 2.0%

[0074] L-64 2.0%

[0075] Tween-20 1.0%

[0076] Sodium Citrate 2.0%

[0077] Citric Acid 2.0%

[0078] KOH (45%) 10.0%

[0079] Wherein, KOH (45%) accounts for 10.0% means that the percentage concentration of 45% KOH in the whole formula is 10.0%. The cleaning solution prepared according to the above ratio has a pH value of 13.6.

[0080] The on-line cleaning performance of the above-mentioned alkaline cleaning solution was tested with Mindray’s BS-400 automatic biochemical analyzer. The test indicators include the residual rate of protein substances, the residual rate of lipid substances, the deposition of reactants, the intra-batch repeatability of clinical projects, and the special cross-contamination. It is the triglyceride reactant cross-cont

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PUM

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Abstract

The invention discloses a cleaning fluid applied for automatic biochemical analyzers, comprising: at least one anion surface active agent, at least one nonionic surface active agent, an alkali metal hydroxide, an alkali metal citrate and a buffer agent for stabilizing pH value above 13.0. The cleaning fluid has low protein residual rate, low fatty material residual rate, good in-batch repeatability, low cross pollution and low reactant deposition rate in clinical application after cleaning. And the cleaning fluid will not affect the test result of biochemical analyzers, and has not corrosion on the liquid circuit system and reaction cup of analyzers. All components of the cleaning fluid can be degraded biologically, to avoid potential environment pollution and meet environment protection requirement.

Description

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Claims

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Application Information

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Owner SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
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