Anticoagulation method for surface of medical polymer material or product

[0023] Embodiment 1: the anticoagulation method of medical polymer material or product surface, comprises the following steps:

[0024] (1) Preparation of heparin-benzalkonium bromide complex:

[0025] 1) Dissolve 0.1g of heparin sodium in 10ml of purified water or distilled water;

[0026] 2) the benzalkonium bromide solution is made into a concentration of 5% (ml / ml) with purified water;

[0027] 3) 5% benzalkonium bromide solution was gradually added dropwise to the above sodium heparin solution until white precipitated suspension appeared. Continue to react for 5 minutes to make it fully react and the white precipitate and solution layering are obvious.

[0028] 4) Filter again with a G2 funnel to obtain a white precipitate. The white precipitate is fully washed and soaked with purified water or distilled water, and washed repeatedly until the white precipitate begins to form agglomerates and no quaternary ammonium salt remains, and a white or light yellow heparin comple

[0037] Embodiment 2: Coating and curing medical polycarbonate (PC) tube:

[0038] 1) Preparation of coating solution:

[0039] Dissolve 10 g of the heparin quaternary ammonium salt complex described in step (1) of Example 1 in 40 ml of methanol and 60 ml of dichloroethane solution, and obtain a colorless and transparent coating solution after fully dissolving.

[0040] 2) Coating:

[0041] Pour the prepared coating solution into a medical PC tube in a 100-level environment, soak for 3 hours to form a stable heparin coating on the surface, take it out, and let it dry naturally.

[0042] 3) Curing treatment:

[0043] ① Prepare the curing agent bifunctional group reagent glutaraldehyde with purified water to a concentration of 1% (ml / ml).

[0044] ②Soak the above-coated medical PC tube in the bifunctional group reagent, and cure it at 60°C for 100 minutes to form a cross-linked heparin polymer coating. Finally, the unreacted bifunctional group reagent was cleaned with purified w

[0045] Embodiment 3: Coating and curing medical silicone rubber (SR) tube:

[0046] 1) Preparation of coating solution:

[0047] Dissolve 1 g of the heparin quaternary ammonium salt complex described in step (1) of Example 1 in 100 ml of chloroform solution, and obtain a colorless and transparent coating liquid after fully dissolving.

[0048] 2) Coating:

[0049] In a 100-level purification environment, apply the prepared coating solution on the surface of the medical SR tube by a combination of flow-through and immersion methods, take it out after 40 minutes, let it dry naturally or blow dry, and return it after 1 to 5 hours. Apply the same method again to form a stable heparin coating on the surface of the medical SR tube and let it dry naturally.

[0050] 3) Curing treatment:

[0051] ① Prepare the curing agent bifunctional group reagent glutaraldehyde with purified water to a concentration of 0.5% (ml / ml).

[0052] ②Soak the above-coated medical SR tube in the bifuncti