Formula and preparation process of escitalopram oxalate effervescent tablet

[0025] A kind of escitalopram oxalate effervescent tablet, its component by weight percentage is: escitalopram oxalate is 3.34g, anhydrous citric acid 17.75g, sodium bicarbonate 29.75g, sucrose 26.62g, orange flavor Flavor 5.74g, Aspartame 8.87g, Macrogol-60007.83g, PVPK 30 0.1g;

[0026] Preparation:

[0027] ① Grind escitalopram oxalate, sodium bicarbonate, anhydrous citric acid, sucrose, and orange flavor to 80 mesh, and sieve aspartame and polyethylene glycol-600 to 80 mesh;

[0028] ②Weigh the prescribed amount of escitalopram oxalate, anhydrous citric acid, aspartame, and orange flavor, mix well, and add 38% of the total mass of PVPK 30 Ethanol solution, making soft materials, granulating with a 20-mesh sieve, drying at 60°C until the moisture content of the granules is ≤1.0%, and sizing with a 18-mesh sieve to obtain granule a;

[0029] ③Weigh the prescribed amount of sodium bicarbonate and sucrose, mix evenly, add PVPK with a total mass of 62% 30 Ethanol solution, mak

[0034] A kind of escitalopram oxalate effervescent tablet, its component by weight percentage is: escitalopram oxalate is 3.34g, anhydrous citric acid 20g, sodium bicarbonate 30g, sucrose 29.56g, orange essence 4g , Aspartame 7g, Macrogol-60006g, PVPK 30 0.1g;

[0035] Preparation:

[0036] ① Grind escitalopram oxalate, sodium bicarbonate, anhydrous citric acid, sucrose, and orange flavor to 80 mesh, and sieve aspartame and polyethylene glycol-600 to 80 mesh;

[0037] ②Weigh the prescribed amount of escitalopram oxalate, anhydrous citric acid, aspartame, and orange flavor, mix well, and add 38% of the total mass of PVPK 30 Ethanol solution, making soft materials, granulating with a 20-mesh sieve, drying at 60°C until the moisture content of the granules is ≤1.0%, and sizing with a 18-mesh sieve to obtain granule a;

[0038] ③Weigh the prescribed amount of sodium bicarbonate and sucrose, mix evenly, add PVPK with a total mass of 62% 30 Ethanol solution, making soft materials,

[0043] A kind of escitalopram oxalate effervescent tablet, its component by weight percentage is: escitalopram oxalate is 3.34g, anhydrous citric acid 18.56g, sodium bicarbonate 30g, sucrose 28g, orange essence 5g , Aspartame 8g, Macrogol-60007g, PVPK 30 0.1g;

[0044] Preparation:

[0045] ① Grind escitalopram oxalate, sodium bicarbonate, anhydrous citric acid, sucrose, and orange flavor to 80 mesh, and sieve aspartame and polyethylene glycol-600 to 80 mesh;

[0046] ②Weigh the prescribed amount of escitalopram oxalate, anhydrous citric acid, aspartame, and orange flavor, mix well, and add 38% of the total mass of PVPK 30 Ethanol solution, making soft materials, granulating with a 20-mesh sieve, drying at 65°C until the moisture content of the granules is ≤1.0%, and sizing with a 18-mesh sieve to obtain granule a;

[0047]③Weigh the sodium bicarbonate and sucrose of the recipe quantity, mix well, add PVPK of 62% of the total mass 30 Ethanol solution, making soft material, gr