Acquiring method and device for mutation sites of genes corresponding to digestive system

A digestive system and gene locus technology, applied in the field of bioinformatics, can solve problems such as limited number of mutation sites, biased prediction results, and inability to determine mutations at the same time

Inactive Publication Date: 2017-03-15
CHENGDU XINYUN DECODING TECH CO LTD
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The existing determination of the mutation of the gene site in the digestive system is usually to obtain the base mutation of the gene site at a specified position of the gene to be tested by chemical means. The number of mutation sites obtained by this acquisition method is limited. Usually only the mutation of one or a few bases can be obtained, and the mutation of as many mutation sites as possible in the gene corresponding to the digestive system in the gene to be tested cannot be determined at the same time, so that the subsequent combination of other information can be used for digestion. There may be large deviations in the prediction results of the prevalence of systemic diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

no. 1 example

[0032] The embodiment of the present application provides a method for obtaining the mutation site of the gene corresponding to the digestive system, which is used to obtain the base mutation status of the mutation site of the gene related to the digestive system in the gene to be tested. See figure 2 , the method includes:

[0033] Step S110: Compare multiple short sequences of the gene to be tested with the reference genome to obtain preliminary mutation site information of the gene to be tested, and the preliminary mutation site information includes mutation bases of multiple preliminary mutation sites And the location information of each preliminary mutation site.

[0034] First, multiple short sequences of the gene to be tested are obtained, which can be output through a second-generation sequencing platform. Align the short sequence of the gene to be tested with the reference genome. For example, if the gene to be tested is a human gene, the reference genome is a hum...

no. 2 example

[0108] This embodiment provides a device 200 for acquiring mutation sites of genes corresponding to the digestive system, please refer to Figure 4 , the device 200 includes:

[0109] The comparison module 210 is used to compare the data of multiple short sequences of the gene to be tested with the reference genome to obtain preliminary variation site information of the gene to be tested, and the preliminary variation site information includes a plurality of preliminary variation sites The mutated bases and the position information of each preliminary mutated site.

[0110] The filtering module 220 is used to delete the variable sites that do not meet the preset retention conditions among the multiple preliminary variable sites according to the preliminary variable site information, and delete the variable sites in the gene to be tested obtained after deletion as the detection point.

[0111] A comparison module 230, configured to compare the site to be tested with multiple ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The application provides an acquiring method and device for mutation sites of genes corresponding to digestive system, and relates to the technical filed of biological information. The method comprises the steps of conducting data comparison between a plurality of short sequences of the genes to be tested and the reference genome to obtain the preliminary variation site information of the genes to be tested; omitting the variation sites which don't meet the preset reservation requirements in the preliminary variation sites according to the preliminary variation site information, and taking the variation sites, obtained after omitted, in the genes to be tested as genes to be inspected; conducting comparison between the genes to be inspected and the multiple mutation sites of the genes corresponding to the digestive system in a digestive system gene pool; obtaining the site mutation conditions of the genes corresponding to the digestive system in the genes to be tested when the mutation sites which have the same positions and mutation basic groups as the mutation sites in the digestive system gene pool exist in the genes to be inspected. The acquiring method and device for the mutation sites of the genes corresponding to the digestive system can acquire the mutation conditions of multiple variation sites, in the variation sites of the genes to be tested, corresponding to the digestive system.

Description

technical field [0001] The present application relates to the field of biological information technology, and in particular, relates to a method and device for obtaining mutation sites of genes corresponding to the digestive system. Background technique [0002] With the development and maturity of medicine, genomics and high-throughput sequencing technology, precision medicine (Precision Medicine) is also applied in countries around the world, becoming a new medical model. Precision medicine is a medical method for disease prevention and treatment that takes into account the differences in personal genes, environment and living habits, and formulates personalized and precise medical and health management plans based on each person's genetic information. [0003] The genetic background of each person is different. In this process, it is necessary to determine the mutation of each person's genome or some genes associated with the corresponding organ or location, so that furth...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/18
CPCG16B20/00
Inventor 范振鑫刘鱼
Owner CHENGDU XINYUN DECODING TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap