Wild canine tapeworm expelling chewable tablet and preparation method thereof
A wild canine, chewable tablet technology, applied in the field of drug research and development, can solve the problems of low bioavailability, difficult to apply to wild canine animal control, insoluble in water, etc., to improve feed intake rate and avoid excessive poisoning. Effect
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Embodiment 1
[0024] A preparation method of a wild canine tapeworm repellent chewable tablet, the specific steps are as follows:
[0025] (1) Weighing and mixing: Accurately weigh 40g of praziquantel and 2580g of filler (wheat flour); weigh 60g of animal muscle and grind it, and add beef essence in a ratio of 20:1; 1% animal fat, mix well to obtain a mixture;
[0026] (2) Granulation: Add dropwise 10% PVP ethanol solution accounting for 10% of the mixture to the mixture obtained in step (1), stir rapidly, and reach the state of "forming into agglomerates when grasped, and disperse when touched", and pass through a 18-mesh sieve Granulate and dry in a thermostat at 70°C for 3 hours to prepare dry granules;
[0027] (3) Tablet compression: Add the dried granules obtained in step (2) into a tablet press machine to compress tablets, and prepare 1000 tablets of wild canid tapeworm repellent chewable tablets, the specification is 0.04g / tablet (i.e. the active ingredient praziquantel 0.04g / pie
Embodiment 2
[0029] A preparation method of a wild canine tapeworm repellent chewable tablet, the specific steps are as follows:
[0030] (1) Weighing and mixing: Accurately weigh 50g of praziquantel, 2560g of filler (highland barley powder); weigh 54g of animal muscle and pulverize, add beef essence in a ratio of 20:1; Add 2% animal fat and mix well to obtain a mixture;
[0031] (2) Granulation: Add dropwise 15% PVP ethanol solution accounting for 5% of the mixture to the mixture obtained in step (1), stir rapidly, and reach the state of "forming into agglomerates when grasped, and disperse when touched", and pass through a 18-mesh sieve Granulate and dry in a constant temperature oven at 60°C for 4 hours to prepare dry granules;
[0032] (3) Tablet compression: Add the dried granules obtained in step (2) into a tablet press to compress tablets, and prepare 1000 tablets of wild canid tapeworm repellent chewable tablets, with a specification of 0.05g / tablet (that is, the active ingredient
Embodiment 3
[0034] A preparation method of a wild canine tapeworm repellent chewable tablet, the specific steps are as follows:
[0035] (1) Weighing: Accurately weigh 60g of praziquantel and 2608g of filler (corn flour); weigh 76g of animal muscle and grind it into pieces, and add beef essence at a ratio of 20:1; 2% tallow, mix well to obtain a mixture;
[0036] (2) Granulation: Add dropwise 6% PVP ethanol solution accounting for 8% of the mixture to the mixture obtained in step (1), stir rapidly, and reach the state of "forming into agglomerates when grasped, and disperse when touched", and pass through a 18-mesh sieve Granulate and dry in a constant temperature oven at 65°C for 3.5 hours to prepare dry granules;
[0037] (3) Tablet compression: Add the dried granules obtained in step (2) into a tablet press to compress tablets, and prepare 1000 tablets of wild canid tapeworm repellent chewable tablets, the specification is 0.06g / tablet (i.e. the active ingredient praziquantel 0.06g /
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