Modeling method for mice with diseases of depression and liver-stagnation and spleen-deficiency syndrome

The invention relates to the technical field of depression research, in particular to a modeling method for mice with diseases of depression and liver-stagnation and spleen-deficiency syndrome. Healthy mice are continuously stimulated for 28 days, each type of stimulation is averagely used for 4 times, and the stimulation types are as follows: water forbidding and food interruption stimulation for24 hours, tail clamping stimulation for 1 min, ice water swimming stimulation at 10 DEG C for 1 min, horizontal shaking continuous stimulation at the frequency of 1 time/s for 5 min, lamplight irradiating stimulation for 24 h, saturated water wet padding stimulation for 24 h or continuous stimulation by inclining a mouse cage by 45 degrees for 24 h; from the fifteenth day to the 28th day of continuous stimulation, 0.5 mL of rheum officinale powder aqueous suspension with the concentration of 15% (wt) is further perfused into stomachs of the mice every day. The obtained model mice have the symptomatic expression of depression and liver-stagnation and spleen-deficiency syndrome, and can be used for further research on pathogenesis and treatment of depression and liver-stagnation and spleen-deficiency syndrome.