Construction method of oral squamous cell carcinoma diagnosis model, marker and application thereof

A technique for squamous cell carcinoma and a construction method, which is applied in the field of constructing a diagnostic model for oral squamous cell carcinoma, can solve the problems of less research on diagnostic biomarkers, etc., and achieve the effect of accurate diagnosis

Active Publication Date: 2021-01-08
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, omics technology has been widely used in the discovery and identification of diagnostic biomarkers for cardiovascular diseases, digestive system diseases, and urinary system diseases, but there are relatively few domestic studies on OSCC diagnostic biomarkers

Method used

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  • Construction method of oral squamous cell carcinoma diagnosis model, marker and application thereof
  • Construction method of oral squamous cell carcinoma diagnosis model, marker and application thereof
  • Construction method of oral squamous cell carcinoma diagnosis model, marker and application thereof

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[0032]Various exemplary embodiments of the present invention will now be described in detail. The detailed description should not be considered as a limitation to the present invention, but should be understood as a more detailed description of certain aspects, characteristics, and embodiments of the present invention.

[0033]It should be understood that the terms described in the present invention are only used to describe specific embodiments and are not used to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that the upper and lower limits of the range and each intermediate value between them are specifically disclosed. Each smaller range between any stated value or intermediate value within the stated range and any other stated value or intermediate value within the stated range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded from

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Abstract

The invention provides an auxiliary diagnosis marker for oral squamous cell carcinoma. The auxiliary diagnosis marker consists of LysoPC(16: 0), LysoPC(18: 1), taurine and glutamic acid. The inventionfurther provides a method for constructing the oral squamous cell carcinoma auxiliary diagnosis model. The method comprises the following steps: 1, acquiring a training case set; 2, collecting a serum sample of the subject, and carrying out ultra-high performance liquid chromatography quadrupole/electrostatic field orbitrap tandem high-resolution mass spectrometry analysis on the serum sample toobtain a plurality of differential metabolites; 3, determining LysoPC(16: 0), LysoPC(18: 1), taurine and glutamic acid as auxiliary diagnosis models of oral squamous cell carcinoma from the pluralityof differential metabolites. The invention provides an auxiliary diagnosis model which has the advantages of being minimally invasive and high in accuracy in diagnosis of oral squamous cell carcinoma.

Description

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Claims

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Application Information

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Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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