Application of combination of NK cells and TFPI in prevention and treatment of nasopharyngeal carcinoma

A technology of NK cells and nasopharyngeal carcinoma, which is applied in the field of medicine, can solve the problems of NK cells with low anti-tumor ability, achieve high market value, improve curative effect, and promote the effect of inhibition

Active Publication Date: 2021-09-28
广州艾克赛斯生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology helps reduce cancer by targeting specific molecules called NfPs (Natural Killer Cellular Factor) with other proteins like VEGFR2 or PTEN. These agents help stimulate natural kills on tumor-associated lymphocytes without harming normal tissue. They are effective at reducing lung metastasis while being less likely than traditional treatments such as chemotheraphy or radiation techniques.

Problems solved by technology

This patented technical problem addressed in this patents relating to developing improved ways to treat nasoepitheliuccinemia caused by noncancer metastasis involving lymphatic fluid accumulations around teeth called pharcochromis sinensis. Current techniques involve administering drugs like caffeine to help reduce pain and inflammations associated with these deposits. Additionally, some other agents used include radioactive rays, cryosurgery, chemical substances, hormones, cytokines, bone marrow stem cells, collagenase injection, radiosensitive necropsia, interferons, growth factors, histamine release stimulators, chlorokynopyridium salt preparative solution, calcium ion supplements, glutaminyltransferases, lysozyme production promoter, and various others.

Method used

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  • Application of combination of NK cells and TFPI in prevention and treatment of nasopharyngeal carcinoma
  • Application of combination of NK cells and TFPI in prevention and treatment of nasopharyngeal carcinoma

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Experimental program
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Effect test

Embodiment 1

[0027] 1. Experimental materials

[0028] 1. Tissue factor pathway inhibitor (TFPI): commercially available;

[0029] 2. Natural killer cells (NK cells): NK cells from human umbilical cord blood;

[0030] 3. Cancer cells: EBV-positive nasopharyngeal carcinoma cells (HK1-EBV);

[0031] 4. Immunodeficient NCG mice: commercially available.

[0032] 2. Experimental group

[0033] 1. Blank control group: EBV-positive nasopharyngeal carcinoma cells were not treated with any drugs.

[0034] 2. TFPI group: EBV-positive nasopharyngeal carcinoma cells were treated with TFPI.

[0035] 3. NK cell group: use NK cells to treat EBV-positive nasopharyngeal carcinoma cells.

[0036] 4. NK cells+TFPI group: NK cells and TFPI were used to treat EBV-positive nasopharyngeal carcinoma cells at the same time.

[0037] 3. Subcutaneous tumor formation experiment in immunodeficient NCG mice

[0038] 1. Divide 5×10 6 EBV-positive nasopharyngeal carcinoma cells (HK1-EBV) were implanted subcutaneousl

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Abstract

The invention provides an application of combination of NK cells and TFPI in prevention and treatment of nasopharyngeal carcinoma. It is found for the first time that a tissue factor pathway inhibitor (TFPI) serving as a natural killer cell (NK cell) anti-nasopharyngeal carcinoma synergist can promote the NK cell to inhibit growth of nasopharyngeal carcinoma cell transplantation tumor and remarkably improve the curative effect of the NK cell in the aspect of nasopharyngeal carcinoma prevention and treatment, so that the TFPI and the NK cell are combined for use, the synergistic interaction effect of the TFPI and the NK cell is exerted, the new application of the NK cells and the TFPI is provided, a new therapeutic medication scheme is provided for treatment of the nasopharyngeal carcinoma, and the NK cells and the TFPI have extremely high market value in the aspect of prevention and treatment of the nasopharyngeal carcinoma.

Description

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Claims

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Application Information

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Owner 广州艾克赛斯生物医药科技有限公司
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