Application of anwuligan or pharmaceutical composition thereof in colorectal cancer treatment

[0033] An embodiment of the present invention discloses an application of anpentapene in the preparation of a drug for treating colorectal cancer. The anpentapene can be used alone or in combination with existing anticancer drugs.

[0034] A large number of studies have found that anpentapene can inhibit the M2 polarization of macrophages, reduce the drug resistance of colorectal cancer induced by M2 macrophages, and enhance the chemosensitivity of colorectal cancer cells.

[0035] Preferably, the dosage of anpentapene is 5-40 mg / kg per day, 2-4 times a week, and the route of administration is oral, and the effect of inhibiting the M2 polarization of macrophages is relatively obvious.

[0036] Exemplarily, the dosage of anpentapene is 10 mg / kg, 3 times a week, 24 hours before the administration of anticancer drugs.

[0037] In order to better illustrate the effect of using anpentapene alone on macrophages in the treatment of colorectal cancer, two sets of experiments are giv

[0045] Another embodiment of the present invention discloses a drug combination for treating colorectal cancer, including drug A and drug B. Wherein, the composition of drug A includes anpentapene; the composition of drug B includes cisplatin.

[0046] Preferably, drug A is used within a preset period of time before taking drug B, so as to reduce the chemosensitivity of colorectal cancer cells to cisplatin.

[0047] It has been found through research that the combination of anpentapene and cisplatin can significantly enhance the therapeutic effect on colorectal cancer.

[0048] Preferably, the above-mentioned preset time period can be given to different people and different animals according to actual needs and experiments, and different time periods can be set, for example, one day (24 h) to one week.

[0049] Preferably, the dosage of drug A should reach the dosage of anpentapene, which is 5-40 mg / kg per day, 2-4 times a week. The route of administration is oral or intraven