Anticancer nanometer targeted administered prescription

一种抗癌药、纳米的技术，应用在抗肿瘤药、药物组合、高分子化合物非有效成分等方向，能够解决磁靶向应用不便、生产工艺复杂、无法精确定位等问题，达到便于大规模工业化生产、生产工艺简单、提高药效和特导性的效果

Inactive Publication Date: 2004-11-17
JIANGXI MEDICINE ACADEME
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many research reports focus on connecting monoclonal antibodies or making magnetic targeting drug delivery systems. The use of monoclonal antibodies to "guidance" has high production costs and complicated production processes. The application of magnetic targeting is inconvenient and cannot be accurately positioned.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] The invention links folic acid with bovine serum albumin as a material for preparing nanospheres, and then encapsulates anticancer drugs (doxorubicin, etc.) to make nanospheres. Its specific preparation process method is as follows: first folic acid (or 5MeH 4 Folic acid) was dissolved in dimethyl sulfoxide, and incubated with 2-10 times 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide at 23°C for 30min to activate folic acid, then added BSA and incubated at 23°C 4h, add ethanolamine, and finally use Sephadex G-25 column to separate to obtain folic acid-BSA, then use folic acid-BSA as material to prepare drug-loaded nanospheres, and use HPLC method to determine the content of doxorubicin in nanospheres.

[0007] HPLC content determination method

[0008] After dissolving the nanospheres, extract doxorubicin with methanol, and measure according to the following method: HPLC chromatographic conditions, YMC-C18H37 chromatographic column (300mm×5mm), mobile phase is methanol...

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PUM

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Abstract

The invention discloses an anti-cancer targeting nano medicine administration preparation, wherein folic acid is connected with cow blood albumen to form the material for preparing nano balls, then the anti-cancer drugs are encapsulated. By using nano balls as the carrying agent, good constancy has been realized. íí

Description

technical field [0001] The invention relates to an anticancer drug targeted nano drug delivery preparation. Background technique [0002] Malignant tumors are common and frequently-occurring diseases that seriously threaten human life and health. In recent years, according to statistics, there are about 4.5 million patients who die of cancer every year in the world, while about 1 million people die of cancer in my country. All countries in the world are paying attention to the research on the prevention and treatment of cancer. Most of the chemotherapeutic drugs currently used clinically use the principle of rapid proliferation of cancer cells to inhibit or kill cancer cells, but normal tissues such as bone marrow cells also have the ability to proliferate rapidly, so the toxic and side effects of most chemotherapeutic drugs also increase with the increase. Therefore, people are looking for "guide" of anticancer drugs to improve the targeting of dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/42A61P35/00
Inventor 朱亮李少华
Owner JIANGXI MEDICINE ACADEME
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