Gas injection amount determining method method in isotope gas analysis, and, isotype gas analyzing and measuring method and apparatus

a technology of isotope gas and amount determination, which is applied in the direction of diagnostic recording/measuring, instruments, applications, etc., can solve the problems of difficult to detect a slight change in concentration ratio, difficult to precisely measure the concentration ratio in expired breath of patients, and measurement error, so as to improve measurement precision and reproducibility

Active Publication Date: 2007-04-05
OTSUKA PHARM CO LTD
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Benefits of technology

The technical effect of this patented measurement device improves its accuracy and reproducibility while making it smaller without requiring more space than what was previously possible.

Problems solved by technology

This patent describes methods for accurately measuring the concentration of certain chemical compounds in biological samples like blood. These techniques involve collecting samples containing specific chemical compounds and measuring their concentration levels through various means. Gas injection devices have been developed to ensure accurate measurements of the concentration of certain chemical compounds. Current methods require precise control over the flow rates of both gases and liquids during the process, but they cannot always achieve desired accuracy due to factors such as temperature changes and humidity differences.

Method used

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  • Gas injection amount determining method method in isotope gas analysis, and, isotype gas analyzing and measuring method and apparatus
  • Gas injection amount determining method method in isotope gas analysis, and, isotype gas analyzing and measuring method and apparatus
  • Gas injection amount determining method method in isotope gas analysis, and, isotype gas analyzing and measuring method and apparatus

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Embodiment Construction

[0030] Referring to the attached drawings, the following description will discuss in detail an embodiment of the present invention in which after a urea diagnostic medicine marked with an isotope 13C has been administered to a living body, the 13CO2 concentration of an expired breath of the living body is spectroscopically measured.

I. Expired Breath Test

[0031] First, an expired breath of a patient before a urea diagnostic medicine is administered, is collected in an expired breath bag. Then, a urea diagnostic medicine is orally administered to the patient. After the passage of about 20 minutes, an expired breath is collected in an expired breath bag in a manner similar to that before administration.

[0032] The expired breath bags be-fore and after administration are respectively set to predetermined nozzles of an isotope gas spectroscopic measurement apparatus. Then, the following automatic measurement is conducted.

II. Isotope Gas Spectroscopic Measurement Apparatus

[0033]FIG. 1 i

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Abstract

As previous processing of measurement in which gas to be measured containing, as gas components, carbon dioxide 13CO2 and carbon dioxide 12CO2, is introduced into a cell, and in which the intensities of transmitted lights having wavelengths suitable for measurement of the respective gas components, are measured and then data-processed to measure the concentrations of the gas components, the air having a predetermined volume Va is sucked by a gas injection device 21, a gas exhaust valve V6 of a cell 11 is closed and the air stored in the gas injection device 21 is transferred to the cell 11 filled with the air at an atmospheric pressure, thereby to pressurize the cell inside. The pressure thus pressurized is measured as P. The cell volume Vc is subtracted from the product obtained by multiplying the sum. V0 of the volume Va and Vc the cell volume Vc, by the ratio P0/P in which P0 is the target pressure of the gas to be measured at which a calibration curve has been prepared for an isotope gas analysis and measurement, thus determining the one-time gas injection amount of the gas injection device 21. Thus, measured concentration variations based on changes in atmospheric pressure can be corrected.

Description

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Claims

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Application Information

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Owner OTSUKA PHARM CO LTD
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