Methods for determining the risk of a systemic lupus erythematosus (SLE) patient to develop neuropsychiatric syndromes

Inactive Publication Date: 2018-08-16
IMMUNARRAY LTD
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  • Abstract
  • Description
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AI Technical Summary

Benefits of technology

This patent describes a new way to diagnose lupus nephritis by using protein antigens that are specific to patients with this condition. These antigens were discovered when researchers tested the response of antibodies from patients with lupus nephritis compared to patients without it. By measuring the reactivity of these antibodies, a highly sensitive and accurate test for lupus nephritis can be developed. This new method can help doctors better diagnose and treat this condition.

Problems solved by technology

However, the diagnosis of neuropsychiatric SLE (NPSLE) remains difficult.
Although the life expectancy of patients with SLE has significantly improved over the past 50 years, NPSLE patients have a poorer quality of life than non-NPSLE patients.
However, in the absence of other diagnostic criteria the usefulness of MRI for the diagnosis of NPSLE is limited, since the lesions it detects are observed in healthy individuals and in many SLE patients with no NP symptoms.

Method used

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  • Methods for determining the risk of a systemic lupus erythematosus (SLE) patient to develop neuropsychiatric syndromes
  • Methods for determining the risk of a systemic lupus erythematosus (SLE) patient to develop neuropsychiatric syndromes
  • Methods for determining the risk of a systemic lupus erythematosus (SLE) patient to develop neuropsychiatric syndromes

Examples

Experimental program
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Effect test

example 1

[0159]Unique Antigen-Autoantibody Reactivity Patterns Capable of Differentiating NPSLE Patients from Non-NPSLE Control Group

[0160]Materials and Methods

[0161]Human Subjects

[0162]The study was approved by the Institutional Review Board of the participating clinical unit; informed consent was obtained from all participants. All patient identifiers were kept confidential.

[0163]Thirty-eight SLE serum samples were obtained from the Einstein Lupus Cohort at the Albert Einstein College of Medicine (Bronx, N.Y.) and tested using the ImmunArray iCHIP, printed with a set of 225 antigens associated with SLE and / or brain injury. All SLE samples satisfied the ACR classification criteria. Twelve of the 38 patients were diagnosed as positive for NPSLE based on the use of a validated questionnaire.

[0164]Antigen Microarrays and Serum Testing

[0165]Antigen microarray chips were prepared as previously described (Quintana et al. Lupus. 2006; 15: 428-30). Briefly, the antigens were spotted on epoxy-activa...

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Abstract

Methods and kits are provided for diagnosing of neuropsychiatric syndromes concurrent with SLE (NPSLE) and for determining whether an SLE subject is at risk of developing a neuropsychiatric disease.

Description

FIELD OF THE INVENTION[0001]The present invention relates to methods for diagnosing neuropsychiatric syndromes concurrent with SLE. The present invention further relates to methods for determining whether an SLE patient is at risk of developing neuropsychiatric syndromes.BACKGROUND OF THE INVENTION[0002]Systemic lupus erythematosus (SLE) is a chronic, recurrent, potentially fatal multisystem inflammatory disorder mainly affecting women. SLE is associated with a large spectrum of autoantibodies. IgG antibodies to more than 100 different antigens including DNA, nucleosomes, histones, viral antigens, transcription factors and more have been reported in different SLE patients (Sherer et al., 2004, Semin. Arthritis. Rheum. 34:501-37).[0003]Peripheral neurologic syndromes and central nervous system (CNS) manifestations are recognized as primary disease manifestations in SLE. Neuropsychiatric SLE (NPSLE) involves a wide range of nervous system disorders, and can affect 50% or more of SLE p...

Claims

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Application Information

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IPC IPC(8): G01N33/68G16B20/30G16B20/50G16B40/20
CPCG01N33/6854G01N2800/30G01N2800/28G01N2333/78G01N33/564G16B20/00G16B40/00G16B20/30G16B20/50G16B40/20
Inventor JAKOBI, KERENREINER-BENAIM, ANAT
Owner IMMUNARRAY LTD
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