Methods and compositions for treatment of diseases

Pending Publication Date: 2022-09-22
TRANEXAMIC TECHNOLOGIES LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013]In another embodiment, the present disclosure relates to a composition for ameliorating or preventing a disease or disease condition. In some embodiments, the composition includes a synthetic lysine analog, derivative, or mimetic. In some embodiments, the synthetic lysine analog, derivative, or mimetic interacts with cells associated with the disease or disease condition to inhibit or prevent replication, survival, or formation of the cells.
[0014]In an additional embodiment, the present disclosure relates to a method of ameliorating aging or impacting the aging process to a patient subjected to environmental factors effecting the aging process. In some embodiments, the method includes administering a composition having a synthetic lysine analog, derivative, or mimetic. In some embodiments, the synthetic lysine analog, derivative, or mimetic inhibits histone acetylation by p300 thereby changing acetylation patterns. In some embodiments, the method further includes, activating autophagy pathways and promoting autophagosome formation.
[0015]In a further embodiment, the present disclosure is related to a composition for ameliorating aging or impacting the aging process to a patient subjected to environmental factors effecting the aging process. In some embodiments, the composition includes a synthetic lysine analog, derivative, or mimetic. In some embodiments, the synthetic lysine analog, derivative, or mimetic inhibits histone acetylation by p300 thereby changing acetyla

Problems solved by technology

Additionally, aging causes a gradual decline in normal physiological functions and represents an additional risk factor for contracting several diseases.
Survival is worse in developing worlds, partly because the types of cancer that are most common there are harder to treat than those associated with developed countries.
The increased risk is believed to be due to the random chance of developing any cancer, the likelihood of surviving the first cancer, the same risk factors that produced the first cancer, and unwanted side effects of treating the first cancer (particularly radiati

Method used

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  • Methods and compositions for treatment of diseases
  • Methods and compositions for treatment of diseases
  • Methods and compositions for treatment of diseases

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Embodiment Construction

[0038]It is to be understood that the following disclosure provides many different embodiments, or examples, for implementing different features of various embodiments. Specific examples of components and arrangements are described below to simplify the disclosure. These are, of course, merely examples and are not intended to be limiting. The section headings used herein are for organizational purposes and are not to be construed as limiting the subject matter described.

[0039]For proliferation and survival of diseases (e.g., cancer), cells require protein-protein, protein-DNA, and protein-RNA interactions involving the three positively charged amino acids lysine, arginine, and histidine. These three positively charged amino acids (lysine, arginine, and histidine) provide the positive charge in the electrostatic bond between positively and negatively charged residues required in multiple protein-protein, protein-DNA, and protein-RNA connections involved in various biological activities

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Abstract

In an embodiment, the present disclosure relates to a method of ameliorating or preventing a disease or disease condition. Generally, the method includes administering a composition having a synthetic lysine analog, derivative, or mimetic. In some embodiments, the synthetic lysine analog, derivative, or mimetic interacts with cells associated with the disease or disease condition to inhibit or prevent replication, survival, or formation of the cells. In another embodiment, the present disclosure relates to a composition having a synthetic lysine analog, derivative, or mimetic for ameliorating or preventing a disease or disease condition. In a further embodiment, the present disclosure is related to a method and composition having a synthetic lysine analog, derivative, or mimetic for ameliorating aging. In an additional embodiment, the present disclosure is related to a method and composition having a synthetic lysine analog, derivative, or mimetic for treatment and prevention of cancer.

Description

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Claims

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Application Information

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Owner TRANEXAMIC TECHNOLOGIES LLC
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