The invention discloses application of a senecio cineraria extract in preparing a drug for treating deposition of liver fat. The use dosage of the senecio cineraria extract is 0.1 to 10g/kg. The application has the advantages that the blank of medical value and therapy effect of active ingredients of senecio cineraria is filled up; the deposition of the liver fat can be decreased by the senecio cineraria extract, the therapy effect is obvious, any toxic or side effect is avoided, and the important meaning is realized for the clinical prevention and control and the improving of living quality of a patient; a safe, effective and economic new method is provided for decreasing the deposition of the liver fat, the theoretical technique and technical support are provided for the clinical application and scientific research, and the application prospect is broad.