The invention relates to a method of detecting and quantifying small peptides derived from proteins from a range of different clinical samples using the
Selective Reaction Monitoring (SRM) profiling technique. By targeting these unique peptides which specifically identify particular proteins, the present invention enables multiple samples to be run in a multiplexed fashion in order to identify, diagnose, quantitate and profile a full range of benign and
pathologic entities, including but not limited to, the complete range of cancers and the spectrum of inflammatory diseases, including
inflammatory cell typing and
bone marrow cell typing. The SRM
assay is capable of performing clinical
blood typing and it can also act as a
diagnostic test to identify women at highest risk for
cervical cancer base on
Human Papillomavirus (HPV) testing.