The invention relates to a high-activity multifunctional laundry bead and a preparation method thereof, and belongs to the technical field of daily chemical detergents. The laundry bead is prepared from dodecyl benzene sulfonate, dodecyl benzene sulfonic acid monoethanol amine salt, oleic acid monoethanol amide polyoxyethylene ether, fatty acid methyl ester ethoxylate, amine oxide, an organic silicon compound, deionized water, propylene glycol, an re-deposition resistant agent, triisopropanol amine, an anti-cross-color agent, a bacteriostatic agent, a compound enzyme, a water softener, a fluorescent whitening agent, a preservative, citric acid, essence and perfume. The raw materials are uniformly mixed and stirred, the pH is adjusted, then discharging is carried out, and finally packagingis performed to obtain the laundry bead. By adding a little amount of solvent and the dissolving property of a nonionic surfactant, the active matter content of the laundry bead can reach 80% and is 3-4 times higher than that of a traditional detergent in the market.