The invention belongs to the technical field of drink processing, and relates to a preparation method of sepia esculenta compound health care tea pills. The preparation method comprises the following steps: firstly, respectively checking and selecting pour wild winter chrysanthemum, Chinese cypress, cattle nose, cuttlebone and sepia esculenta, cleaning the raw materials through acetic acid aqueous solution, then drying the raw materials, respectively crushing the wild winter chrysanthemum and Chinese cypress, digesting the wild winter chrysanthemum and Chinese cypress in purified water, soaking the wild winter chrysanthemum and Chinese cypressin alcohol aqueous solution, and making the wild winter chrysanthemum and Chinese cypress into plant raw material mixture after centrifugation, grinding the cattle nose, the cuttlebone and the sepia esculenta into granular mixture powder, and then adding beta cyclodextrine and purified water into the cattle nose, the cuttlebone and the sepia esculenta, stirring and digesting the raw materials under controlled temperature, filtering and draining off the raw materials, so as to obtain granular mixture, putting the plant raw material mixture and the granular mixture into a stirring pot, adding white granulated sugar into the stirring pot, stirring and mixing the plant raw material mixture and the granular mixture, so as to obtain tea raw material, then adding purified water to the tea raw material, boiling the tea raw material on soft fire, so as to form extract material, finally, preparing the extract material into spherical tea pills, and packing the tea pills into a non-woven bag to package the tea pills. The preparation method has the advantages of mature preparation technology, natural and green raw materials, high convenience in drinking, fragrant taste and significant efficacy.