The invention provides a purification method for protective
meropenem. The purification method comprises the following steps: controlling a temperature to be 10-30 DEG C, adding an
organic solvent A into a protective
meropenem feed liquid, washing an organic phase with a water phase
solvent for three times so as to obtain a protective
meropenem organic phase feed liquid, concentrating the protective meropenem organic phase feed liquid so as to obtain a concentrated solution, dropwise adding a reverse
solvent into the concentrated solution, and carrying out filtering, washing and
drying so as to obtain the protective meropenem. According to the invention, different
crystallization solvents are creatively used for crystallizing and purifying the protective meropenem feed liquid to obtain high-purity protective meropenem, so high-purity meropenem is prepared. The method provided by the invention has the advantages of simple operation, good purification effect and the like, and can be applied to industrial purification and production of meropenem.