Purification method for protective meropenem

[0051] A purification method for protecting meropenem, comprising the following steps:

[0052] (1) Add 99.54g of N,N-dimethylformamide and 15g of meropenem side chains to the reaction flask, stir and dissolve to obtain a clear solution, add 25g of meropenem core to it, stir the solution until it becomes clear, and cool down to

[0053] -60~-50℃, gradually drop 7.42g N,N-diisopropylethylamine into the reaction bottle

[0054] , and reacted for 18 hours to obtain a protected meropenem feed solution.

[0055] The content of impurity IV in the side chain of meropenem was 6ppm, and the content of impurity V in the protected meropenem feed solution detected by high performance liquid chromatography (HPLC) was 0.03%.

[0056] (2) At 10-15°C, add 265g of dichloromethane to the protected meropenem feed solution obtained in step (1), and wash the organic phase three times with 200g of 10% sodium chloride solution respectively to obtain protected Meropenem organic phase material liqui...

[0068] A purification method for protecting meropenem, comprising the following steps:

[0069] (1) Add 140g of dichloromethane and 15g of meropenem side chains into the reaction flask, stir and dissolve to obtain a clear solution, add 25g of meropenem core to it, stir the solution until clear, cool to -25~-20°C, and 7.26 g of triethylamine was gradually added dropwise into the reaction flask, and after the dropwise addition was completed, the reaction was carried out at -25 to -20°C for 18 hours to obtain a protected meropenem feed solution.

[0070] The content of impurity IV in the side chain of meropenem was 45 ppm; the content of impurity V in the feed liquid detected by high performance liquid chromatography (HPLC) was 0.07%.

[0071] (2) Add 190 g of ethyl acetate to the protected meropenem feed solution obtained in step (1) at 10-15°C, and wash the organic phase three times with 200 g of deionized water respectively to obtain the protected meropenem organic phase feed ...

[0076] A purification method for protecting meropenem, comprising the following steps:

[0077] (1) Add 99.54g of N,N-dimethylformamide, 15g of meropenem side chain, 25g of meropenem nucleus and 2.6g of impurity IV into the reaction flask, stir the solution until it becomes clear, and cool down to -10~0℃ , 7.42g of N,N-diisopropylethylamine was gradually added dropwise into the reaction flask, and after the dropwise addition was completed, the reaction was carried out at -10 to 0°C for 20 hours to obtain a protected meropenem feed solution.

[0078] The content of impurity V in the feed liquid detected by high performance liquid chromatography (HPLC) was 19.70%.

[0079] (2) Add 265g of dichloromethane to the protected meropenem feed solution obtained in step (1) at 10-15°C, and wash the organic phase three times with 200g of 5% sodium acetate solution respectively to obtain protected meropenem Raopenem organic phase material liquid, concentrate the protected meropenem organi...