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2 results about "Protein structure" patented technology

Protein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule. Proteins are polymers – specifically polypeptides – formed from sequences of amino acids, the monomers of the polymer. A single amino acid monomer may also be called a residue indicating a repeating unit of a polymer. Proteins form by amino acids undergoing condensation reactions, in which the amino acids lose one water molecule per reaction in order to attach to one another with a peptide bond. By convention, a chain under 30 amino acids is often identified as a peptide, rather than a protein. To be able to perform their biological function, proteins fold into one or more specific spatial conformations driven by a number of non-covalent interactions such as hydrogen bonding, ionic interactions, Van der Waals forces, and hydrophobic packing. To understand the functions of proteins at a molecular level, it is often necessary to determine their three-dimensional structure. This is the topic of the scientific field of structural biology, which employs techniques such as X-ray crystallography, NMR spectroscopy, and dual polarisation interferometry to determine the structure of proteins.

Application of KMT2D in preparation of antitumor drugs

ActiveCN112057608ARegulation of proliferationRegulation of apoptosisPeptide/protein ingredientsTransferasesProtein structureProtein level
The invention discloses an application of KMT2D in the preparation of antitumor drugs, and belongs to the technical field of biological medicines. A protein structure of KMT2D is analyzed through a bioinformatics means, two essentially disordered structures LCD1 and LCD2 of the KMT2D protein are finally obtained through screening, and the influence of the two structures on the KMT2D function is researched by combining the gene editing technology, the change (including mRNA and protein levels) of a KMT2D enzymatic complex is further researched, and thereby a foundation is laid for the deep understanding of a mechanism of KMT2D promoting tumor.
Owner:NANTONG UNIVERSITY
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