Disclosed is a slow release injection agent of anticancer composition containing taxone and synergistic agent, which comprises slow release microspheres and dissolvent, wherein the slow release microballoons comprise anti-
cancer active constituents and slow release auxiliary materials, the dissolvent being conventional dissolvent or specific dissolvent containing suspension
adjuvant. The
viscosity of the suspension
adjuvant is 100-3000cp (at 20-30 deg C), and is selected from
sodium carboxymethylcellulose, the anticancer active constituents include taxone and / or taxone synergistic agent selected from antimitotic drugs, alkylating agent and / or antimetabolites, the slow release auxiliary materials are selected from
polyphosphate ester copolymers such as p(LAEG-EOP), p(DAPG-EOP),
copolymer of
polyphosphate ester with
polylactic acid, Polifeprosan, di-aliphatic acid and sebacylic acid,
copolymer or blend of poly(erucic aciddipolymer-sebacylic acid) or poly(
fumaric acid-sebacylic acid). The anticancer composition can also be prepared into slow release implanting agent, for injection or placement in or around tumor with a period of effective concentration maintenance over 40 days, as well as the
treatment effect of appreciably lowering general reaction of the drugs, and improving the
treatment effect of the non-operative treatment methods such as
chemotherapy.