Anticancer medicine composition of taxane and its synergist

[0124] Put 90, 90 and 80mg p(BHET-EOP / TC), BHET-EOP: TC is 80:20) copolymer into three containers of A, B and C respectively, and then add 100 ml of dichloromethane to each , after dissolving and mixing, add 10mg paclitaxel, 10mg colchicine, 10mg paclitaxel and 10mg colchicine respectively, shake up again and prepare 10% paclitaxel, 10% colchicine, and 10% paclitaxel and 10 % colchicine microspheres for injection. Then suspend the microspheres in physiological saline containing 15% mannitol to prepare the corresponding suspension-type sustained-release injection. The release time of the slow-release injection in physiological saline in vitro is 40-50 days, and the release time in mice subcutaneously is more than 50 days.

[0126] The method step of being processed into slow-release injection is identical with embodiment 1, but difference is that used auxiliary material is the p(BHET-EOP / TC) of 50: 50, containing anticancer active ingredient and weight percent thereof are:

[0127] (1) 5-30% paclitaxel or docetaxel;

[0128](2) 5-30% of cytochalasin, alcodazole, procodazole, arsenic, giradazole or nocodazole; or

[0129] (3) Combination of 5-30% taxane or docetaxel and 5-30% colchicine, alcodazole, procodazole, arsenic, giraladazole or nocodazole.

[0131] Put 70 mg of p(LAEG-EOP) with a peak molecular weight of 10,000-25,000 into three containers of A, B, and C, respectively, and then add 100 ml of dichloromethane to each, dissolve and mix well, and pour into the three containers respectively Add 30mg of docetaxel, 30mg of cyclophosphamide, 15mg of docetaxel and 15mg of cyclophosphamide, shake up again and use the spray drying method to prepare 30% docetaxel, 30% cyclophosphamide, 15% docetaxel and 15 % cyclophosphamide injection microspheres. The dried microspheres are suspended in physiological saline containing 1.5% sodium carboxymethylcellulose to prepare the corresponding suspension-type sustained-release injection. The release time of the slow-release injection in physiological saline in vitro is 55-65 days, and the release time in mice subcutaneously is about 60 days.