2 results about "Transesterification" patented technology

The invention provides a phosphatidyl nanometer prodrug released by enzymatic response and a preparation method and application thereof. The phosphatidyl nanometer prodrug is formed by a hydrophilia antitumor drug containing primary alcohol and a phospholipid compound through bonding of a phosphorus oxygen bond under the catalytic action of phospholipase D. The invention further provides application of the phosphatidyl nanometer prodrug released by enzymatic response for releasing the antitumor drug to tumor tissue in a targeting mode. The hydrolysis/transesterification two-way reaction characteristic of the phospholipase D highly-expressed in tumor tissue is utilized creatively, and the amphipathicity phosphatidyl nanometer prodrug is obtained through biological catalytic synthesis of the phospholipase D in vitro; when the prodrug is accumulated to tumors in a targeting mode for responding to the phospholipase D to trigger hydrolysis, the antitumor drug is specifically released, and meanwhile the purposes of safety, stability and effective release of the targeting medicine are achieved.

The invention relates to a preparation method of a 3853 oxide (with the full name of 2, 2, 6, 6-tetramethyl-piperidinooxy stearate), and aims to solve the problem about generation of the product in the market at present. The manufacturing technique of the 3853 oxide adopts and introduces a novel structure, adopts a transesterification route, post-processing adopts oxidation filtering to replace previous water washing, so that waste water discharge is reduced. The product grade is improved through introducing a polymerization inhibitor 701 into a group, and besides, the methyl stearate raw material is low in cost, so that popularization of the photostabilizer market is facilitated.