Probucol controlled-release tablet for treatment of hypercholesteremia and production method thereof

[0037] Example 1 Probucol Sustained Release Tablets (500mg)

[0038] Prescription composition:

[0039] Element mg / tablet Probuka 500 lactose 80 HPMCK15M 220 PVP-K30 30 5% starch slurry Appropriate amount Magnesium stearate 8 Gastric Opadry 20

[0040] production method:

[0041] Pass the prescribed amount of Probucol through a 100-mesh sieve, and pass the prescribed amount of HPMC-K15M, lactose and PVP-K30 through a 80-mesh sieve. Mix the above raw and auxiliary materials evenly, make soft material with 5% starch slurry, granulate with 18-mesh sieve, dry at 50°C, granulate with 20-mesh sieve, add prescription amount of magnesium stearate, mix evenly, and compress into tablets to obtain Chips, spare;

[0042] Put the above tablet cores into the coating pan, the speed is 30 rpm, the temperature is controlled at 50-60°C, and the prepared gastric-soluble Opadry film coating solution (the prescribed amount of gastric-solub

[0043] Example 2 Probucol Sustained Release Tablets (1000mg)

[0044] Prescription composition:

[0045] Element mg / tablet Probuka 1000 microcrystalline cellulose 180 HPMCK100M 350 PVP-K30 50 5% starch slurry Appropriate amount Magnesium stearate 15 Gastric Opadry 35

[0046] production method:

[0047] Pass the prescribed amount of Probucol through a 100-mesh sieve, and pass the prescribed amount of HPMC-K100M, microcrystalline cellulose and PVP-K30 through an 80-mesh sieve respectively. Mix the above raw and auxiliary materials evenly, make soft material with 5% starch slurry, granulate with 18-mesh sieve, dry at 50°C, granulate with 20-mesh sieve, add prescription amount of magnesium stearate, mix evenly, and compress into tablets to obtain Chips, spare;

[0048] Put the above tablet cores into the coating pan, the speed is 30 rpm, the temperature is controlled at 50-60°C, and the prepared gastric-soluble Opadry