Measuring properties of an anatomical body

an anatomical body and measurement technology, applied in the field of measuring the properties of anatomical bodies, can solve the problems of contaminated needles or lances, local skin damage, bleeding, etc., and achieve the effect of effective measuring one or more surface properties, compliance gain and/or skin stiffness

Inactive Publication Date: 2010-01-07
MASSACHUSETTS INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]Skin sensor apparatus and methods described herein use specially tailored stimulation to effectively measure one or more properties of the surface of an anatomical body, such as the compliance gain and / or stiffness of skin.

Problems solved by technology

Because of the density of this layer of cells, moving compounds across the skin, either into or out of the body, can be difficult.
However, these methods suffer from several major disadvantages: local skin damage, bleeding, and risk of infection at the injection site, and creation of contaminated needles or lances that must be disposed.
Further, when these devices are used to inject drugs in agriculture animals, the needles break off from time to time and remain embedded in the animal.
Needleless injection devices have been proposed to overcome the problems associated with needles, but the proposed devices present different problems.
For example, some needleless injection devices rely on spring actuators that offer limited control.
Others use solenoids, compressed air or hydraulic actuators also offer limited control.

Method used

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Embodiment Construction

[0037]A description of preferred embodiments of the invention follows.

[0038]Referring to FIGS. 1A-1C, there are shown various views of a drug delivery device used to inject a liquid formulation of an active principle, for example, a drug, into biological body such as an agriculture animal or human being. The delivery device is generally identified as 10 in the illustrated embodiment as well as in other embodiments described later. The drug is initially contained in a chamber 12 (FIG. 5A) and is injected out through an orifice or output port 14 into the body.

[0039]A nozzle is typically used to convey the drug to the skin at the required speed and diameter to penetrate the skin as required. The nozzle generally contains a flat surface, such as the head 17 that can be placed against the skin and an orifice 14. It is the inner diameter of the orifice 14 that controls the diameter of the drug stream. Additionally, the length of an aperture, or tube, defining the orifice 14 also controls ...

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PUM

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Abstract

A medical device includes a sensor that is configured to measure a property of an outer layer of an anatomical body surface. The sensor includes a source probe configured stimulate a local surface of the outer layer of an anatomical body surface. The sensor also includes a detector configured to measure a response of the outer layer resulting from the source probe stimulation. A controller coupled to the source probe and the sensor drives the source probe using a tailored stochastic sequence and determines the property of the outer layer using the measured response received from the detector. The sensor can be used with medical devices, such as drug delivery devices including microneedle transport devices and needleless injection devices.

Description

RELATED APPLICATIONS[0001]This application is a divisional of U.S. application Ser. No. 10 / 657,724, filed Sep. 8, 2003, which is a Continuation of U.S. application Ser. No. 10 / 656,806, filed on Sep. 5, 2003 which claims the benefit of U.S. Provisional Application Nos. 60 / 409,090, filed Sep. 6, 2002 and 60 / 424,114, filed Nov. 5, 2002.[0002]The entire teachings of the above applications are incorporated herein by reference.BACKGROUND OF THE INVENTION[0003]Injection of a liquid such as a drug into a human patient or an agriculture animal is performed in a number of ways. One of the easiest methods for drug delivery is through the skin which is the outermost protective layer of the body. It is composed of the epidermis, including the stratum corneum, the stratum granulosum, the stratum spinosum, and the stratum basale, and the dermis, containing, among other things, the capillary layer. The stratum corneum is a tough, scaly layer made of dead cell tissue. It extends around 10-20 microns...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M5/31A61B5/00A61M5/30A61B5/103A61D7/00A61M5/00A61M5/20
CPCA61B5/0051A61B5/442A61M2205/11A61M5/30A61M2205/33A61M5/204
Inventor HUNTER, IAN W.
Owner MASSACHUSETTS INST OF TECH
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