POSS-PEG (Polyhedral Oligomeric Silsesquioxane-Polyethylene Glycol) hybrid hydrogel as well as preparation method and application thereof
A hydrogel and hybridization technology, applied in medical science, prosthesis, etc., can solve the problem of photoinitiator toxicity and other problems, achieve good mechanical strength, reduce damage or loss, and fast gelation time
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[0036] The principles and features of the present invention will be described below in conjunction with examples. The examples cited are only used to explain the present invention and are not used to limit the scope of the present invention.
[0037] 1. Preparation of POSS-PEG Hybrid Hydrogel
[0038] The POSS-PEG hybrid hydrogel is prepared by the following method: 4-arm-PEG-MAL (Beijing Jiankai Technology Co., Ltd.) and POSS-SH (Sigma) are dissolved in 3 mL of tetrahydrofuran, stirred at room temperature for 3.5 hours, and then removed Solvent the POSS-PEG prepolymer; then dissolve the POSS-PEG prepolymer and the matrix metalloproteinase substrate peptide (Shanghai Jier Biochemical Technology Co., Ltd.) in 3 mL of triethanolamine with a pH of 7.4 and mix well to obtain a pre-gelled solution; Finally, the above-mentioned pre-gelling solution was transferred to five 600 μl molds, and reacted in a 37°C biochemical incubator to prepare a hydrogel. The molecular weight of 4-arm-PEG-MAL,
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