Preparation of procyanidine multiple emulsion hydrogel

A technology of proanthocyanidins and multiple emulsions, which can be used in emulsion delivery, medical preparations containing non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as poor stability, low bioavailability, and complex anthocyanin structures

Pending Publication Date: 2021-06-22
NANJING POLYTECHNIC INSITUTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to the complex structure of proanthocyanidins, poor stability, and the shortcomings of being easily decomposed when exposed to light, they have not been resolved, and most of the products are capsules, tablets, etc. when

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] 1. Instruments and reagents

[0012] Electronic analytical balance BS124S (Beijing Sartorius Instrument System Co., Ltd.), magnetic stirring electric heating constant temperature water bath EMS-30 (Shanghai Qiaoyue Electronics Co., Ltd.), electric heating constant temperature blast drying oven DHG-9030A (Shanghai Jinghong Test Equipment Co., Ltd.)

[0013] Proanthocyanidins (98%) (Shaanxi Chengqian Biotechnology Co., Ltd.), chitosan (Shanghai Aikang Chemical Co., Ltd.), sodium tripolyphosphate (Sinopharm Chemical Reagent Co., Ltd.), acetylated monoglyceride (ACE) (Shanghai Lingyue Industrial Co., Ltd.), polyethylene glycol 30-dipolyhydroxystearate (P135) (Guangzhou Ge Leishi Trading Co., Ltd.), sorbitan decahydrate monooleate polyoxyethylene ether (Tween 80) (Qingdao Youso Chemical Technology Co., Ltd.), corn oil (Wilmar International), deionized water (Wahaha Group)

[0014] 2. Preparation

[0015] Heat 18.4% corn oil, 3.68% acetylated monoglyceride, 1.92% polyethylene

Embodiment 2

[0019] As described in Example 1, the loading amount of proanthocyanidins was selected to be 0.04 g.

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PUM

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Abstract

The invention relates to preparation of a natural active matter procyanidine multiple emulsion hydrogel, which comprises the following steps: heating corn oil, acetylated monoglyceride, polyethylene glycol 30-dipolyhydroxystearate and a deionized water solution containing procyanidine in a water bath at 65 DEG C, magnetically stirring for 15 minutes at the rotating speed of 600 rpm to prepare primary emulsion, slowly dropwise adding the primary emulsion into a deionized water solution containing Tween 80, heating in a water bath at the temperature of 50 DEG C, and magnetically stirring for 10 minutes at the rotating speed of 400 rpm to prepare the procyanidine multiple emulsion. The prepared procyanidine multiple emulsion and 5% chitosan hydrogel are stirred for 5 min at the mass ratio of 1: 1 and the speed of 100 rpm and fully mixed, then the mixture is dropwise added into a 2.5% sodium tripolyphosphate cross-linking agent for cross-linking, and cross-linking is conducted for 20 min, and the procyanidine multiple emulsion hydrogel ball can be prepared.

Description

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Claims

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Application Information

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Owner NANJING POLYTECHNIC INSITUTE
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