Methods, compositions and kits for use in prognosis, characterization and treatment of cancer

a technology prognosis, applied in the field of molecular genetic markers for prognosis, characterization and treatment of cancer, can solve the problems of subjective interpretation and health risks, add another dimension of complexity to the regulation of hormone response, and difficult to establish er expression with breast cancer prognosis, etc., to enhance the specificity of hybridization, prolong the life, and enhance the effect of activity

Inactive Publication Date: 2007-05-17
AGENCY FOR SCI TECH & RES
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  • Abstract
  • Description
  • Claims
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Benefits of technology

This patented technology allows for modification of certain natural bases found within an analog called adenosine (A) which has been added onto DNA sequences like ACGTGGGTT). These modifications make it more stable against degradation compared to other similar structures present on DNA strands themselves. By changing this modified structure back during synthesis, researchers have discovered new compounds containing different chemical groups attached at various positions around them.

Problems solved by technology

This patents discusses two main technical problem addressed during this patented study: how accurately predict who will develop invasiveness towards breast carcinoma when it becomes symptomatic due to advanced stages of disease and environmental conditions like radiation exposures. Current diagnostic tools involve various biopsy procedures involving surgery followed by analysis based on specific molecular markers associated therewith. These tests require expensive equipment and trained staff, while others lack accuracy because they rely heavily on human judgment rather than objective measurements. Therefore, new approaches aim at developing better understanding of breast pathology through nonclonality and interference phenomena related to estrogens' action within breast tissues.

Method used

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  • Methods, compositions and kits for use in prognosis, characterization and treatment of cancer
  • Methods, compositions and kits for use in prognosis, characterization and treatment of cancer
  • Methods, compositions and kits for use in prognosis, characterization and treatment of cancer

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[0163] Reference will now be made in detail to exemplary embodiments of the invention. While the invention will be described in conjunction with the exemplary embodiments, it will be understood that they are not intended to limit the invention to these embodiments. On the contrary, the invention is intended to cover alternatives, modifications and equivalents, which may be included within the spirit and scope of the invention.

[0164] ERα and ERβ bind to the same response element but are associated with different growth effects. In order to assess distinct signatures that can discern the biological differences, the global transcriptional effect of ERβ expression on ERα action was examined.

[0165] In order to characterize the effect of ERβ expression on hormone response in ERα-positive breast tumor cells and to decipher the functions of a / P heterodimers, T-47D (ERα+ / ERβ−) cells were stably transfected with an inducible ERβ expression construct to generate subline T-47 Dbeta. Using hi

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Abstract

The present invention provides methods, compositions and kits for the prognosis, characterization and treatment of cancers. The methods, compositions and kits of the invention comprise a set of markers whose expression is correlated with estrogen receptor beta function. Therefore, the methods, compositions and kits of the invention find particular use in endocrine-related cancers such as breast cancers.

Description

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Claims

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Application Information

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Owner AGENCY FOR SCI TECH & RES
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