Methods and kits for predicting the risk of diabetes associated complications using genetic markers and arrays
a technology of genetic markers and arrays, applied in the field of kits for predicting the risk of diabetes associated complications, can solve the problems of not being able to predict which subjects with diabetes are at increased risk of developing renal complications, diabetes nephropathy is a leading cause of morbidity and mortality in diabetic patients
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[0055]Our cohort consists of 1338 unrelated patients with type 2 diabetes from the Hong Kong Diabetes Registry (HKDR) enrolled between 1995 and 1998. All subjects were of southern Han Chinese ancestry residing in Hong Kong. Patients with classical type 1 diabetes (defined as acute presentation with diabetic ketoacidosis, heavy ketonuria (>3+), or continuous requirement of insulin within 1 year of diagnosis) were excluded. In addition, patients with incomplete clinical information (N=4), follow-up period less than 3 years (N=145), requirement of dialysis at baseline (N=1), or had ESRD defined as estimated glomerular filtration rate (eGFR) less than 15 ml / min per 1.73 m2 at enrollment (N=16) were excluded. The study design, ascertainment, inclusion criteria and phenotyping of the study subjects have been described6 27. For this analysis, a total of 1172 unrelated patients with type 2 diabetes were included (mean (±SD) age 56.0±11.9 years, 41.3% male, disease d...
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