Pharmaceutical Composition for Improving Health, Cure Abnormalities and Degenerative Disease, Achieve Anti-aging Effect of Therapy and Therapeutic Effect on Mammals and Method Thereof
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[0245]Referring now to Example 1, Burkitt lymphoma (Namalwa line) and acute promyelocyte leukemia (HL-60 line) cells under the action of components containing 39K, 64Zn and 24Mg, the main objective was to assess the phenotypic differences between cells of Burkitt lymphoma and acute promyelocyte leukemia under the action of components containing 39K, 64Zn and 24Mg. The assessment of changes in the cell phenotype was carried out in relation to the cytoskeleton and adhesion proteins in the human tumor cells of Burkitt lymphoma (Namalwa line) and acute promyelocyte leukemia (HL-60 line) after their exposure to the effect of components containing 39K, 64Zn and 24Mg.
[0246]The chemical form of the active ingredients is KCL for 39K and sulfates for 64Zn and 24Mg. The following antigens / markers that distinguish a differentiation status of the cells and their malignancy were used in the research: ICAM-1 or CD54 marker is a single chain glycoprotein with a molecular mass of 55 kDa. It is an int
Example
[0310]Example 2, Section 2 will now be discussed. Immunocytochemistry of adhesion proteins, cytoskeleton (cadherins) and CD 44 stem cell marker after their exposure to the action of 39K, 64Zn and 24Mg on a model of renal cell carcinoma (PA) in a rat. Detection of cumulative properties of 64Zn. Cadherins are a group of glycosylated proteins and they are mainly responsible for the formation of cell-cell interactions providing adhesion between two identical molecules that are expressed on the surfaces of two cells of one and the same type. Besides the physical contact that cadherins provide between the two cells, they facilitate the transfer of a number of signals through cytoskeletal structures thus controlling cell growth and differentiation. Cadherins appear mainly in intercellular adhesion at the stages of morpho- and organogenesis. They provide structural integrity of tissues (especially the epithelial monolayer).
[0311]When making the immunocytochemistry (ICC) assay, cells on microsc
Example
Example 6. Zinc (Zn-64) and Aspartic Acid Complex Production Process
[0471]Preparation Process of 64Zne Aspartate
[0472]64Zne aspartate (racemic) having the following formula (in which “64Zn2+” refers, in this one instance, to Zn2+ enriched for 64Zn) was prepared in the experiment.
[0473]At the first stage, zinc oxide enriched for 64Zn was prepared using 64Zne sulfate as the starting compound.
64ZneSO4+2NaHCO3→64ZneO+Na2SO4+2CO2+H2O
[0474]For this purpose, 64Zne sulfate (zinc was at least 99.9% 64Zn, although 64Zne of lower purity may be effective) in an amount of 0.01 mole) was dissolved in 150 ml of water (T=50-70° C.) wherein 1.68 g (0.02 mole) of sodium bicarbonate was added in small portions, to prevent severe foaming, with constant stirring in a magnetic stirrer. After completion of foaming the solution was stirred for another 30 minutes and then left for 1 hour until a white precipitate was formed. During this process, the temperature was maintained at about 60° C. to prevent crystal
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