Oral compositions and the preparation methods thereof

a technology of oral compositions and compositions, applied in the field of veterinary medicine, can solve the problems of unsatisfactory parenteral route for animal administration, unsatisfactory animal treatment, and quite restrictive for the owner, and achieve the effect of improving treatment complian

Active Publication Date: 2020-11-19
CEVA SANTE ANIMALE
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented method allows create a special type of product that makes it easier than regular medication forms like pills because they are easy-to-use without having them taste bad when taken whole due to their hardness. These products include dry particles mixed with liquid ingredients before being pressed into pill shape. They also contain flavoring agents added during manufacturing.

Problems solved by technology

There exist technical problem addressed in this patents relating to delivering veterinary medicine products safely and effectively during orally treatments due to their poor handling behavior caused by swallowing them alone. Existing methods involve making certain forms like powders, liquids, pastilles, etc, which require time from production until final product formation. Additionally, existing techniques involving injection pose challenges related to dosage accuracy and ease of use despite being able to mix soluble drugs together shortly before shaping.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oral compositions and the preparation methods thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

Process to Manufacture a Soft Tablet Comprising (Doxycycline)

[0132]In a granulator, all powder ingredients are mixed together in the amounts specified below:

Doxycycline hyclate23.08gYeast extract52.95gChicken flavor12.46gMaltodextrin43.26gPregelatinized starch37.37gGuar gum3.27gXanthan gum1.40gDextrose26.47gMicrocrystalline cellulose17.13gCroscarmellose14.02gPEG 60006.23g

[0133]Then, humectants are sprayed onto the blend (sorbitol 30.21 g and glycerin 26.47 g premixed together) followed by the oily humectant soya oil (20.24 g). The resulting material is mixed to generate wet granules.

[0134]The wet granules are then spread on tray and left standing for 24 hours at a temperature of about 20° C.

[0135]The granules are then milled with an oscillating granulator through a 1250 μm sieve

[0136]Granules were spread and left at ambient temperature for 6 hours.

[0137]The resulting granules were first blended in a blender with 17.27 g of microcrystalline cellulose, followed by addition of 6.80 g of s

example 2

Soft Tablet Composition Comprising Milbemycin and Praziquantel

[0144]In a granulator, all powder ingredients are mixed together in the amounts specified below:

Milbemycin4gPraziquantel10gMalted yeast52.94gChicken flavor10.90gMaltodextrin39.87gPregelatinized starch43.60gGuar gum3.27gXanthan gum1.40gDextrose31.14gMicrocrystalline cellulose18.68gCroscarmellose14.01gPEG 60006.23g

[0145]Then, humectants are sprayed onto the blend (sorbitol 30.21 g and glycerin 24.91 g premixed together) followed by the oily humectant soya oil (20.24 g). The resulting material is mixed to generate wet granules.

[0146]The wet granules are then spread on tray and left standing for 24 hours at a temperature of about 20° C.

[0147]The granules are then milled with an oscillating granulator through a 1250 μm sieve

[0148]Granules were spread and left at ambient temperature for 6 hours.

[0149]The resulting granules were first blended in a blender with 20.40 g of microcrystalline cellulose, followed by addition of 6.80 g of

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Temperatureaaaaaaaaaa
Temperatureaaaaaaaaaa
Lengthaaaaaaaaaa
Login to view more

Abstract

The present invention relates to a process for preparing a solid composition comprising at least one active ingredient and at least one excipient comprising: i) mixing said at least one active ingredient and said at least one excipient in a granulator to obtain wet granules; ii) spreading wet granules on a tray and let stand for 2 to 24 hours between 15 and 25° C.; iii) compressing granules obtained after step ii) with a tablet press; and iv) collecting the solid composition. The invention further relates a solid composition obtained by such process.

Description

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Owner CEVA SANTE ANIMALE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap