Nutritional composition for the treatment of metabolic diseases

a technology for metabolic diseases and nutrients, applied in the field of nutritional compositions, can solve the problems of acid-base balance alteration, unbalance towards the use of synthetic amino acids, etc., and achieve the effects of reducing the risk of side effects, reducing the risk of renal damage and bone fragility

Pending Publication Date: 2021-10-21
AJINOMOTO CAMBROOKE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a new formula for making food with fewer harmful ingredients like synthetic amino acids. This results in less harming the body's metabolic processes and can help reduce symptoms associated with phenylketonurics such as kidney damage or fracture.

Problems solved by technology

The technical problem addressed by this patented invention is how to provide an effective supplementation or replacement for insufficient caloric intake during pregnancy when treating inherited metabolic conditions such as nephrosis caused by phenylketoneuromyia (PEM).

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0104]Composition for use in the treatment of phenylketonuria or to maintain the acid-base balance in a subject, having the following formulation:

ComponentsQuantityEquivalent Proteins, g100gMethionine, mg2500mgCysteine, mg1000mgPhosphorus, mg1417mgChlorine, mg833mgPotassium, mg1833mgMagnesium, mg583mgCalcium, mg1997mgSodium, mg1332mgPral, mEq−22.3

example 2

Comparative Example

[0105]The Applicant has analysed the formulation and calculated the PRAL of protein-based formulations which do not match the quality and quantitative characteristics of the compositions of the invention.

[0106]Hereinafter formulations of the compositions of the invention and comparative nutritional products / supplements and the related PRAL values are compared.

[0107]Analyses have shown that the compositions having formulations different from the invention have a positive PRAL, whereas the invention compositions such as the one indicated in Example 1 have a negative PRAL.

[0108]It is clear by the comparison that a negative PRAL is obtained as requested only with the composition of the invention.

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PUM

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Abstract

A composition for preventing or treating a metabolic disease, in particular phenylketonuria, comprising sulfur amino acids and minerals is provided, wherein said sulfur amino acids comprise a combination of methionine and cysteine in a methionine/cysteine ratio of 2.2-2.7:1 and said minerals comprise sodium, potassium, magnesium, calcium, chlorine, phosphorus. The composition of the invention is formulated to provide a negative PRAL value, preferably with −35<PRAL<−20 values mEq/day on 100 g of equivalent proteins.

Description

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Claims

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Application Information

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Owner AJINOMOTO CAMBROOKE INC
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